×

Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease

  • US 7,829,531 B2
  • Filed: 03/20/2009
  • Issued: 11/09/2010
  • Est. Priority Date: 07/31/2002
  • Status: Expired due to Term
First Claim
Patent Images

1. A drug-linker-antibody conjugate of Formula Ia:


  • Lprivate use character ParenopenstAa-Ww

    Yy-D)p



    Iaor a pharmaceutically acceptable salt thereof,wherein,L- is an antibody that immunospecifically binds to a cancer cell antigen which is on the surface of a cancer cell;

    -Aa-Ww

    Yy

    is an enzymatically cleavable linker unit that links the Drug unit and the antibody, wherein;

    -A- is a Stretcher unit;

    a is 1;

    each —

    W—

    is independently an Amino Acid unit;



    Y—

    is a self-immolative Spacer unit;

    w is an integer ranging from 2 to 12,y is 1 or 2;

    p ranges from 1 to about 20; and

    -D is a Drug unit of the formula

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×