Receptor associated protein (RAP) conjugates
First Claim
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1. A conjugate comprising a receptor associated protein (RAP) polypeptide and a therapeutic or diagnostic/investigational agent, wherein the RAP polypeptide consists of an amino acid sequence at least 80% identical to amino acids 221-323 of RAP (SEQ ID NO:
- 1).
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Abstract
The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
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13 Claims
- 1. A conjugate comprising a receptor associated protein (RAP) polypeptide and a therapeutic or diagnostic/investigational agent, wherein the RAP polypeptide consists of an amino acid sequence at least 80% identical to amino acids 221-323 of RAP (SEQ ID NO:
Specification