Planning system, method and apparatus for conformal radiation therapy

• US 7,831,289 B2
• Filed: 10/07/2004
• Issued: 11/09/2010
• Est. Priority Date: 10/07/2003
• Status: Active Grant

• Current Assignee: Best Medical International Incorporated (TeamBest Group)
• Original Assignee: Best Medical International Incorporated (TeamBest Group)
• Inventors: Romesberg, Merle III, Riker, Robert
• Primary Examiner(s): Le; Long V
• Assistant Examiner(s): Weatherby; Ellsworth
• Application Number:
  US10/960,424
• Publication Number:
  US 20050111621A1
• Time in Patent Office: 2,224 Days
• Field of Search: 378/65, 600/407, 600/427
• US Class Current: 600/407
• CPC Class Codes: A61N 2005/1074 Details of the control system, e.g. user interfaces
• CPC Class Codes: A61N 5/1031 using a specific method of dose optimization
• CPC Class Codes: A61N 5/1042 with spatial modulation of the radiation beam within the treatment head
• CPC Class Codes: G16H 20/40 relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• CPC Class Codes: G16H 70/20 relating to practices or guidelines

Abstract

A system and associated methods to determine an optimal radiation beam arrangement are provided. The system includes a computer planning apparatus which includes a treatment plan optimization computer having a memory and an input device in communication with the treatment plan optimization computer to provide user access to control functions of plan optimization software. An image gathering device is in communication with the treatment plan optimization computer through a communications network to provide an image slice of the tumor target volume and the non-target structure volume. The plan optimization software computationally obtains and then optimizes a proposed radiation beam arrangement iteratively based on constraints to form an optimized radiation beam arrangement. A conformal radiation therapy delivery device in communication with the treatment plan optimization computer through the communications network then applies the optimized radiation beam arrangement to the patient.

Claims

1. A system to determine an optimal radiation beam arrangement for applying radiation to a tumor target volume while minimizing radiation of a non-target structure volume in a patient, the system comprising a computer planning apparatus including:

a treatment plan optimization computer having a memory to store data and treatment plan optimization software therein; and

an input device in communication with the treatment plan optimization computer to provide user access to control functions of the treatment plan optimization software;

the treatment plan optimization software comprising a set of instructions that, when executed by the treatment plan optimization computer, causes the computer to perform operations to computationally obtain a proposed radiation beam arrangement and to computationally iteratively optimize the proposed radiation beam arrangement based on a plurality of constraints to form the optimized radiation beam arrangement, the treatment plan optimization software including a graphical user interface to display an at least two-dimensional image slice of the tumor target volume and the non-target structure volume, graphical objects, and graphical representations of radiation dose distribution calculated for each iteration of the proposed radiation beam arrangement overlaid upon the displayed image slice, the operations comprising;

receiving inputs from the input device representing direct graphical user manipulation of a graphical representation of radiation dose distribution for a current iteration of the proposed radiation beam arrangement displayed on the graphical user interface, and

responsive to user manipulation of the displayed graphical representation of radiation dose distribution for the current iteration of the proposed radiation beam arrangement, computationally obtaining and providing data to graphically display a graphical representation of radiation dose distribution for a next iteration of the proposed radiation beam arrangement which substantially realizes the graphically altered radiation dose distribution, to thereby iteratively form the optimized radiation beam arrangement;

the graphical representation of the radiation dose distribution for the current iteration of the proposed radiation beam arrangement displayed on the graphical user interface and directly graphically manipulated via the input device, comprising one or more of the following;

an isodose plot including a plurality of isodose contours according to the current proposed radiation beam arrangement overlaid upon the image slice of the target tumor volume and the non-target structure volume, at least one of the plurality of isodose contours of the isodose plot directly graphically manipulatable by a user to graphically alter proposed radiation dose to at least one volume of interest to produce the next iteration of the proposed radiation beam arrangement which substantially realizes the graphically altered radiation dose, the at least one volume of interest comprising one or more of the following;

the target tumor volume and the non-target structure volume, and

a plurality of dose volume histogram curves according to the current proposed radiation beam arrangement, at least one dose volume histogram curve of the plurality of this volume histogram curves directly graphically manipulatable by the user to graphically alter proposed radiation dose to the at least one volume of interest to produce the next radiation beam arrangement which substantially realizes the graphically altered radiation dose.

2. The system as defined in claim 1,

wherein the graphical representation of radiation dose distribution for the current iteration of the proposed radiation beam arrangement is in the form of the isodose plot including the plurality of isodose contours;

and

wherein each isodose contour of the plurality of isodose contours of the isodose plot is directly graphically manipulatable by the user via manipulation of the input device to graphically interface with the respective isodose contour to graphically alter the respective isodose contour to thereby correspondingly alter radiation dose to the at least one volume of interest to produce the optimized radiation beam arrangement.

3. The system as defined in claim 1,

wherein the graphical representation of radiation dose distribution for the current iteration of the proposed radiation beam arrangement is in the form of the plurality of dose volume histogram curves;

and

wherein each dose volume histogram curve of the plurality of dose volume histogram curves is directly graphically manipulatable by the user via manipulation of the input device to graphically interface with the respective dose volume histogram curve to graphically alter the respective dose volume histogram curve to thereby correspondingly alter radiation dose to the at least one volume of interest to produce the optimized radiation beam arrangement.

22. The system as defined in claim 1, wherein the direct graphical user manipulation comprises dragging one of the plurality of graphically displayed isodose contours from a portion of the tumor target volume responsive to user input to a graphically displayed screen pointer through the input device.

23. The system as defined in claim 1, wherein the direct graphical user manipulation comprises dragging one of the plurality of graphically displayed isodose contours into a portion of the tumor target volume responsive to user input to a graphically displayed screen pointer through the input device.

24. The system as defined in claim 1, wherein the direct graphical user manipulation comprises dragging one of the plurality of graphically displayed isodose contours from a portion of the non-target structure volume responsive to user input to a graphically displayed screen pointer through the input device.

25. The system as defined in claim 1, wherein the direct graphical user manipulation comprises dragging one of the plurality of graphically displayed isodose contours into a portion of the non-target structure volume responsive to user input to a graphically displayed screen pointer through the input device.

26. The system as defined in claim 1, wherein the direct graphical user manipulation comprises dragging one of the plurality of graphically displayed dose volume histogram curves to reduce a level of excess dose for a given percentage of the tumor target volume responsive to user input to a graphically displayed screen pointer through the input device.

27. The system as defined in claim 1, wherein the direct graphical user manipulation comprises dragging one of the plurality of graphically displayed dose volume histogram curves to increase a level of dose for a given percentage of the tumor target volume responsive to user input to a graphically displayed screen pointer through the input device.

28. The system as defined in claim 1, wherein the direct graphical user manipulation comprises dragging one of the plurality of graphically displayed dose volume histogram curves to reduce a level of excess dose for a given percentage of the non-target structure volume responsive to user input to a graphically displayed screen pointer through the input device.

4. A non-transitory computer readable medium comprising a computer program stored thereon to determine an optimized radiation beam arrangement for applying radiation to a target tumor volume while minimizing radiation to a non-target structure volume in a patient, the computer program comprising a set of instructions that, when executed by a computer, causes the computer to perform the following operations:

providing data to graphically display an image slice of the target tumor volume and the non-target structure volume;

providing data to graphically display radiation dose for the target tumor volume and for the non-target structure volume on the image slice and in a form of a first isodose plot including a plurality of isodose contours according to a first radiation beam arrangement, the plurality of isodose contours of the first isodose plot being directly graphically manipulatable by a user to graphically alter the radiation dose to at least one volume of interest to produce a second radiation beam arrangement which substantially realizes the graphically altered radiation dose, the at least one volume of interest comprising one or more of the following;

the target tumor volume and the non-target structure volume;

receiving inputs representing direct graphical user manipulation of a graphically displayed user-selected isodose contour of the plurality of isodose contours of the first isodose plot according to the first radiation beam arrangement; and

responsive to the direct graphical user manipulation of the graphically displayed user-selected isodose contour, computationally obtaining, and providing data to graphically display, radiation dose for the target tumor volume and the non-target structure volume on the image slice in a form of a second isodose plot including a plurality of isodose contours according to the second radiation beam arrangement.

5. The non-transitory computer readable medium as defined in claim 4, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a pointing device to graphically alter the graphically displayed user-selected isodose contour of the plurality of isodose contours of the first isodose plot according to the first radiation beam arrangement; and

responsive to a user input to the pointing device, establishing a constraint along a user selected line connecting a start-drag point having a desired level of dose associated with the user-selected isodose contour and an end-drag point having an undesirable level of dose, and setting the level of dose at the end-drag point substantially equal to the desired level of dose, to thereby form the second radiation beam arrangement.

6. The non-transitory computer readable medium of claim 5,

wherein the constraint established along the user selected line constrains dose along the user selected line between the start-drag point and the end-drag point to a value level not to exceed the desired level of dose when the undesirable level of dose is greater than the desired level of dose;

and

wherein the constraint established along the user selected line constrains dose along the user selected line to a value level not below the desired level of dose when the undesirable level of dose is less than the desired level of dose.

7. The non-transitory computer readable medium as defined in claim 4, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a pointing device to graphically alter the graphically displayed user-selected isodose contour of the plurality of isodose contours of the first isodose plot according to the first radiation beam arrangement;

responsive to a user input to the pointing device, selecting a portion of the user-selected isodose contour having a user desired level of dose; and

responsive to the user dragging the selected portion of the user-selected isodose contour with the pointing device along a user desired path from a first selected position on the image slice to a second selected position on the image slice, relocating the isodose contour substantially adjacent the user desired path, to thereby form the second radiation beam arrangement.

8. The non-transitory computer readable medium as defined in claim 4, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a pointing device to graphically alter the graphically displayed user-selected isodose contour of the plurality of isodose contours of the first isodose plot according to the first radiation beam arrangement; and

responsive to a user selection of the user-selected isodose contour according to the first radiation beam arrangement, setting a value of radiation dose within the user-selected isodose contour substantially equal to a value of radiation dose outside the isodose contour, to thereby form the second radiation beam arrangement.

9. The non-transitory computer readable medium of claim 4, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a user controlled input device to receive one or more of the following;

a minimum radiation dose and a maximum radiation dose, for one or more of the following;

the target tumor volume and the non-target structure volume, to define an extremum value input; and

responsive to the extremum value input, constraining isodose contour manipulation of the user-selected isodose contour by the user to prevent an undesirable collateral dose variation.

10. The non-transitory computer readable medium as defined in claim 4, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a user controlled input device to receive a user desired balance between maintaining dosimetric quality and maintaining radiation delivery efficiency for a radiation delivery device, to define an efficiency threshold; and

responsive to the efficiency threshold, constraining isodose contour manipulation of the user-selected isodose contour by the user to maintain radiation delivery efficiency above the efficiency threshold.

29. The non-transitory computer readable medium as defined in claim 4, wherein the received inputs representing direct graphical user manipulation of the graphically displayed user-selected isodose contour comprise inputs representing a user, through use of a pointing device, dragging a portion of the user-selected isodose contour from a location within a portion of the tumor target volume.

30. The non-transitory computer readable medium as defined in claim 4, wherein the received inputs representing direct graphical user manipulation of the graphically displayed user-selected isodose contour comprise inputs representing the user, through use of a pointing device, dragging a portion of the user-selected isodose contour into a location within a portion of the tumor target volume.

31. The non-transitory computer readable medium as defined in claim 4, wherein the received inputs representing direct graphical user manipulation of the graphically displayed user-selected isodose contour comprise inputs representing the user, through use of a pointing device, dragging a portion of the user-selected isodose contour from a location within a portion of the non-target structure volume.

32. The non-transitory computer readable medium as defined in claim 4, wherein the received inputs representing direct graphical user manipulation of the graphically displayed user-selected isodose contour comprise inputs representing the user, through use of a pointing device, dragging a portion of the user-selected isodose contour into a location within a portion of the non-target structure volume.

11. A non-transitory computer readable medium comprising a computer program stored thereon to determine an optimized radiation beam arrangement for applying radiation to a target tumor volume while minimizing radiation to a non-target structure volume in a patient, the computer program comprising a set of instructions that, when executed by a computer, causes the computer to perform the following operations:

providing data to graphically display radiation dose for the target tumor volume and the non-target structure volume in the form of a first plurality of dose volume histogram curves according to a first radiation beam arrangement, the plurality of dose volume histogram curves being directly graphically manipulatable by a user to graphically alter radiation dose to at least one volume of interest to produce a second radiation beam arrangement which substantially realizes the graphically altered radiation dose, the at least one volume of interest comprising one or more of the following;

the target tumor volume and the non-target structure volume;

receiving inputs representing direct graphical user manipulation of a graphically displayed user-selected dose volume histogram curve of the plurality of dose volume histogram curves according to the first radiation beam arrangement; and

responsive to the direct graphical user manipulation of the graphically displayed user-selected dose volume histogram curve, computationally obtaining, and providing data to graphically display, radiation dose for the target tumor volume and the non-target structure volume in the form of a second plurality of dose volume histogram curves according to the second radiation beam arrangement.

12. The non-transitory computer readable medium as defined in claim 11, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a pointing device to graphically alter the graphically displayed user-selected dose volume histogram curve of the plurality of dose volume histogram curves according to the first radiation beam arrangement;

responsive to a user input to the pointing device, selecting a portion of the user-selected dose volume histogram curve located at a first selected position and indicating a first percentage of the target tumor volume permitted to receive more than a predetermined dose level of radiation; and

responsive to the user dragging the selected portion of the user-selected dose volume histogram curve with the pointing device along a user desired path to a second selected position, altering the respective percentage of target tumor volume permitted to receive more than the predetermined dose level of radiation, to thereby form the second radiation beam arrangement.

13. The non-transitory computer readable medium as defined in claim 11, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a user controlled input device to receive one or more of the following;

a minimum radiation dose and a maximum radiation dose, for one or more of the following;

the target tumor volume and the non-target structure volume, to define an extremum value input; and

responsive to the extremum value input, constraining dose volume histogram curve manipulation of the user-selected dose volume histogram by the user to prevent an undesirable collateral dose variation.

14. The non-transitory computer readable medium as defined in claim 11, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a user controlled input device to receive a user desired balance between radiation dosimetric cost and radiation delivery efficiency for a radiation delivery device, to define an efficiency threshold; and

responsive to the efficiency threshold, constraining dose volume histogram curve manipulation of the user-selected dose volume histogram by the user to maintain radiation delivery efficiency above the efficiency threshold.

33. The non-transitory computer readable medium as defined in claim 11, wherein the computer program further comprises instructions that, when executed by the computer, causes the computer to perform the following operations:

interfacing with a pointing device to graphically alter the graphically displayed user-selected dose volume histogram curve of the plurality of dose volume histogram curves according to the first radiation beam arrangement;

responsive to a user input to the pointing device, selecting a portion of the user-selected dose volume histogram curve located at a first selected position and indicating a first percentage of the non-target structure volume permitted to receive more than a predetermined dose level of radiation; and

responsive to the user dragging the selected portion of the user-selected dose volume histogram curve with the pointing device along a user desired path to a second selected position, altering the respective percentage of non-target structure volume permitted to receive more than the predetermined dose level of radiation, to thereby form the second radiation beam arrangement.

15. A method of determining an optimized radiation beam arrangement for applying radiation to a target tumor volume while minimizing radiation to a non-target structure volume in a patient, the method comprising the steps of:

graphically displaying an image slice of the target tumor volume and the non-target structure volume;

graphically displaying radiation dose for the target tumor volume and for the non-target structure volume on the image slice and in the form of a first isodose plot including a plurality of isodose contours according to a first radiation beam arrangement defining a first treatment plan; and

directly graphically manipulating a graphically displayed user-selected isodose contour of the plurality of isodose contours of the first isodose plot with a pointing device by a user to alter the radiation dose for at least one volume of interest, the at least one volume of interest comprising one or more of the following;

the target tumor volume and the non-target structure volume; and

displaying a second isodose plot including a plurality of isodose contours according to a second radiation beam arrangement defining a second radiation treatment plan which substantially realizes the corresponding graphically altered radiation dose.

16. The method as defined in claim 15, wherein the step of directly graphically manipulating the graphically displayed user-selected isodose contour comprises the steps of:

graphically selecting with the pointing device a portion of the user-selected isodose contour located at a first selected position and having a desired first level of dose;

graphically dragging the selected portion of the user-selected isodose contour with the pointing device from the first selected position on the image slice to a second selected position on the image slice having an undesirable second level of dose; and

responsive to the movement of the selected portion of the user-selected isodose contour from the first selected position to the second selected position, setting the second level of dose for the second selected position substantially equal to the desired first level of dose, to thereby form the second treatment plan.

17. The method as defined in claim 16, further comprising the step of:

establishing a constraint between the first and the second selected positions on the image slice;

wherein the constraint constrains dose directly between the first and the selected positions to a value level not to exceed the desired level of dose when the undesirable level of dose is greater than the desired level of dose; and

wherein the constraint constrains dose directly between the first and the selected positions to a value level not below the desired level of dose when the undesirable level of dose is less than the desired level of dose.

18. The method as defined in claim 15, wherein the step of directly graphically manipulating the graphically displayed user-selected isodose contour comprises the steps of:

graphically selecting with the pointing device a portion of the user-selected isodose contour located at a first selected position and having a user desired level of dose;

graphically marking with the pointing device a user desired path from the first selected position on the image slice to a second selected position on the image slice adjacent the separate portion of the isodose contour, substantially encircling a portion of the image slice encircled by the isodose contour; and

responsive to the marking of the user desired path, forming the second treatment plan having radiation dose adjacent the user desired path constrained to the user desired level of dose.

19. The method as defined in claim 15, wherein the step of directly graphically manipulating the graphically displayed user-selected isodose contour comprises the steps of:

graphically selecting with the pointing device the user-selected isodose contour according to the first radiation beam arrangement; and

responsive to the selection of the user-selected isodose contour, remediating a value of radiation dose within the user-selected isodose contour to a value approximately equal a value of radiation dose outside the user-selected isodose contour, thereby forming the second radiation beam arrangement.

34. The method as defined in claim 15, wherein the step of directly graphically manipulating the graphically displayed user-selected isodose contour comprises the step of:

dragging a portion of the user-selected isodose contour from a location within a portion of the tumor target volume with use of the pointing device.

35. The method as defined in claim 15, wherein the step of directly graphically manipulating the graphically displayed user-selected isodose contour comprises the step of:

dragging a portion of the user-selected isodose contour into a location within a portion of the tumor target volume with use of the pointing device.

36. The method as defined in claim 15, wherein the step of directly graphically manipulating the graphically displayed user-selected isodose contour comprises the step of:

dragging a portion of the user-selected isodose contour from a location within a portion of the non-target structure volume with use of the pointing device.

37. The method as defined in claim 15, wherein the step of directly graphically manipulating the graphically displayed user-selected isodose contour comprises the step of:

dragging a portion of the user-selected isodose contour into a location within a portion of the non-target structure volume with use of the pointing device.

20. A method of determining an optimized radiation beam arrangement for applying radiation to a target tumor volume while minimizing radiation to an non-target structure volume in a patient, the method comprising the steps of:

graphically displaying radiation dose for the target tumor volume and for the non-target structure volume in the form of a plurality of dose volume histogram curves according to a first radiation beam arrangement defining a first treatment plan; and

directly graphically manipulating a graphically displayed user-selected dose volume histogram curve of the plurality of dose volume histogram curves with a pointing device by a user to alter the radiation dose for at least one volume of interest, the at least one volume of interest comprising one or more of the following;

the target tumor volume and the non-target structure volume; and

displaying the user-selected dose volume histogram curve according to a second radiation beam arrangement defining a second treatment plan which substantially realizes the corresponding graphically altered radiation dose.

21. The method as defined in claim 20, wherein the step of directly graphically manipulating the graphically displayed user-selected dose volume histogram curve comprises the steps of:

graphically selecting a portion of the user-selected dose volume histogram curve at a first selected position with the pointing device, the selected portion of the dose volume histogram curve indicating a first percentage of the target tumor volume permitted to receive more than a preselected dose level of radiation;

graphically dragging the selected portion of the user-selected dose volume histogram curve with the pointing device from the first selected position along a user desired path to a second selected position indicating a second percentage of the target tumor volume permitted to receive more than the preselected dose level of radiation; and

responsive to the movement of the selected portion of the user-selected dose volume histogram curve from the first selected position to the second selected position, altering the percentage of the target tumor volume permitted to receive more than the predetermined dose level of radiation.

38. The method as defined in claim 20, wherein the step of directly graphically manipulating the graphically displayed user-selected dose volume histogram curve comprises the steps of:

graphically selecting a portion of the user-selected dose volume histogram curve at a first selected position with the pointing device, the selected portion of the dose volume histogram curve indicating a first percentage of the non-target structure volume permitted to receive more than a preselected dose level of radiation;

graphically dragging the selected portion of the user-selected dose volume histogram curve with the pointing device from the first selected position along a user desired path to a second selected position indicating a second percentage of the non-target structure volume permitted to receive more than the preselected dose level of radiation; and

responsive to the movement of the selected portion of the user-selected dose volume histogram curve from the first selected position to the second selected position, altering the percentage of the non-target structure volume permitted to receive more than the predetermined dose level of radiation.