X-ray mammography with tomosynthesis

• US 7,831,296 B2
• Filed: 11/26/2003
• Issued: 11/09/2010
• Est. Priority Date: 11/27/2002
• Status: Active Grant

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Shaw, Ian, Ren, Baorui, Stein, Jay A., DeFreitas, Kenneth F., Smith, Andrew P., Ruth, Chris
• Primary Examiner(s): Le; Long V
• Assistant Examiner(s): Weatherby; Ellsworth
• Application Number:
  US10/723,486
• Publication Number:
  US 20050113681A1
• Time in Patent Office: 2,540 Days
• Field of Search: 378/37, 600/407, 600/425, 600/426, 600/427, 600/429
• US Class Current: 600/427
• CPC Class Codes: A61B 6/025 Tomosynthesis
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/464 involving a plurality of displays
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/482 involving multiple energy imaging
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography

Abstract

A method and system for producing tomosynthetic images of a patient'"'"'s breast. An x-ray source that delivers x-rays through a breast immobilized and compressed between a compression paddle and a breast platform and form an image at a digital x-ray receptor panel. Multiple x-ray images are taken as the x-ray source and the receptor move relative to the immobilized breast. In one preferred embodiment, the x-ray source travels from −15° to +15°. The source can travel in an arc around the breast while the receptor travels linearly while remaining parallel and at the same distance from the breast platform. The sets of x-ray image data taken at different angles are combined to form tomosynthetic images that can be viewed in different formats, alone or as an adjunct to conventional mammograms.

Claims

1. A method of imaging a patient'"'"'s breast with x-rays using a flat panel digital x-ray imager to obtain both two dimensional (2D) image data for a conventional mammogram data and three-dimensional (3D) image data for tomosynthesis images in a single breast compression, using an anti-scatter grid in obtaining some but not all the image data, comprising:

immobilizing a patient'"'"'s breast between an x-ray source and a flat panel digital x-ray imager;

energizing the x-ray source to emit x-rays at each of a plurality of different angular positions of the source relative to the breast while the breast remains immobilized, and concurrently using the imager to derive x-ray projection image data for the respective positions;

wherein the image data for at least one of said positions, called hereafter a mammogram position, are taken at a view matching that of a conventional CC and/or MLO view used in conventional mammography, and the image data for a plurality of other positions, called hereafter tomosynthesis positions, are taken at other relative angles of the source and breast;

wherein the x-ray dose to the patient'"'"'s breast when taking said image data for each of said tomosynthesis positions is less than the x-ray dose when taking said image data for said mammogram position, and the x-ray dose for said mammogram position is similar to a dose used for a conventional mammogram;

using an anti-scatter grid between the patient'"'"'s breast an the imager for at least the mammogram position but not for at least some of the tomosynthesis positions; and

processing the image data taken for the mammogram position to form and display a mammogram and using the image data taken for said tomosynthesis positions to form and display tomosynthesis images of the breast.

2. The method of claim 1, wherein the image data for each of said tomosynthesis positions are taken at a patient x-ray dose that is much less than for the image data for mammogram position.

3. The method of claim 1, wherein the step of energizing the x-ray source at different angular positions comprises energizing the source intermittently during a continuous movement thereof relative to the breast covering at least some said positions.

4. The method of claim 3, wherein the energizing step further includes energizing the source while stationary relative to the breast for at least one of said positions.

5. The method of claim 1, wherein the image data for the mammogram position are acquired when the source is stationary relative to the breast.

6. The method of claim 1, wherein the step of energizing the x-ray source at different angular positions comprises keeping the source stationary relative to the breast at a number of said positions.

7. The method of claim 1, wherein at least some of the tomosynthesis images conform to image planes that are generally parallel to that of the mammogram.

8. The method of claim 1, wherein at least some of the tomosynthesis images conform to image plane that are non-parallel to that of the mammogram.

9. The method of claim 1, wherein the source at said mammogram position is at an angle of substantially 0°

at which a center ray of the x-rays is substantially normal to the x-ray imager.

10. The method of claim 1, wherein the image data for said mammogram position are taken before the image data for the tomosynthesis positions.

11. The method of claim 1, wherein the image data for the mammogram position is taken after the image data for the tomosynthesis positions.

12. The method of claim 1, wherein the image data for the mammogram position are taken after the image data for some of the tomosynthesis positions but before the image data for other tomosynthesis positions.

13. The method of claim 1, wherein the image data for each of the tomosynthesis positions are acquired with the use of substantially higher x-ray source kV compared with the kV used for the image data acquired at the mammogram position.

14. The method of claim 1, wherein the image data are acquired with x-rays emitted from a Tungsten x-ray target.

15. The method of claim 1, wherein at least some of the image data are acquired with x-rays at a kVp range substantially higher than 25 kVp but no more than 50 kVp.

16. The method of claim 1, wherein at least some of the image data are acquired with x-ray in a range from 25 kVp up to 50 kVp.

17. The method of claim 1, wherein said angular positions extend over a range of no more than 60°

.

18. The method of claim 1 including displaying the mammogram and tomosynthesis images for concurrent viewing.

19. The method of claim 1 including displaying the mammogram and tomosynthesis images on the same screen.

20. The method of claim 1 including displaying the mammogram and tomosynthesis images on adjacent screens.

21. The method of claim 1, wherein the tomosynthesis images represent thin slices of the breast that are essentially planar sections through the breast.

22. The method of claim 1, wherein the tomosynthesis images represent thick slices of the breast, about 5 to about 10 mm thick.

23. A combination mammogram/tomosynthesis system comprising:

an x-ray source, a flat panel digital x-ray imager, and a breast support configured to immobilize a patient'"'"'s breast between the source and the imager;

a source support configured to selectively move the source relative to the breast support between different angular positions of the source relative to the breast support;

a control configured to selectively energize the source to emit x-rays through the breast support to the imager, while a patient'"'"'s breast remains immobilized in the breast support at each of said different angular positions;

wherein at least one of said angular positions is a mammogram position that is the same or similar to a position for a conventional mammogram but others of said positions are tomosynthesis positions that are different from conventional mammogram positions;

wherein said x-ray source is configured to apply an x-ray dose to the patient'"'"'s breast in each of said tomosynthesis positions that is less than the x-ray dose applied to the breast in said mammogram position, and the x-ray dose for said mammogram position is similar to a dose used for a conventional mammogram;

an anti-scatter grid configured to be selectively movable in the path of said x-rays from the breast to the imager, said grid being in said path for the mammogram position but being out of said path for at least some of the tomosynthesis positions; and

a processor configured to use an output of said imager for said mammogram and tomosynthesis positions of the source relative to the immobilized breast to form at least one mammogram image for display and tomosynthesis images of the breast for display.

24. The system of claim 23, wherein the control is configured to energize the source to emit a patient x-ray dose for each of the tomosynthesis positions that is much less than the patient x-ray dose for the mammogram position.

25. The system of claim 23, wherein the control is configured to energize the x-ray source at different angular positions intermittently during a continuous movement of the source relative to the breast covering at least some said positions.

26. The system of claim 23, wherein the control is configured to energize the source while the source is stationary relative to the breast for at least one of said positions.

27. The system of claim 23, wherein the control is configured to energize the source for the mammogram position when the source is stationary relative to the breast.

28. The system of claim 23, wherein the control is configured to energize the x-ray source at different angular positions relative to the breast when the source is stationary relative to the breast at each of a number of said positions.

29. The system of claim 23, wherein the processor is configured to form at least some of the tomosynthesis images to conform to image planes that are generally parallel to that of the mammogram position.

30. The system of claim 23, wherein the processor is configured to form at least some of the tomosynthesis images to conform to image plane that are non-parallel to that of the mammogram position.

31. The system of claim 23, wherein the control is configured to place the source at said mammogram position at an angle of substantially 0°

at which a center ray of the x-rays is substantially normal to the x-ray imager.

32. The system of claim 23, wherein the control is configured to place the source for taking image data for said mammogram position before taking image data for the tomosynthesis positions.

33. The system of claim 23, wherein the control is configured to place the source for taking image data for the mammogram position after taking image data for the tomosynthesis positions.

34. The system of claim 23, wherein the control is configured to place the source for taking image data for the mammogram position after taking image data for some of the tomosynthesis positions but before taking image data for other tomosynthesis positions.

35. The system of claim 23, wherein the control is configured to energize the source for taking image data for each of the tomosynthesis positions at substantially higher x-ray source kV compared with the kV used for acquiring the image date at the mammogram position.

36. The system of claim 23, wherein the source comprises a Tungsten x-ray target emitting x-rays toward said imager.

37. The system of claim 23, wherein the source is configured to emit x-rays at a kVp range substantially higher than 25 kVp when the imager is acquiring image data at least at some of said positions.

38. The system of claim 23, wherein the source is configured to emit x-ray in a range up to 50 kVp when the imager is acquiring image data for at least some said positions.

39. The system of claim 23, wherein the control is configured to move the source through angular positions that extend over a range of no more than 60°

.

40. The system of claim 23, comprising at least one display configured for displaying the mammogram and tomosynthesis images for concurrent viewing.

41. The system of claim 23, comprising at least one display configured for displaying the mammogram and tomosynthesis images on the same screen.

42. The system of claim 23, comprising at least one display configured for displaying the mammogram and tomosynthesis images on adjacent screens.

43. The system of claim 23, wherein the processor is configured to form tomosynthesis images that represent thin slices of the breast that are essentially planar sections through the breast.

44. The system of claim 23, wherein the processor is configured to form tomosynthesis images that represent thick slices of the breast, about 5 to about 10 mm thick.