Mapping physiological functions of tissues in lungs and other organs

• US 7,831,298 B1
• Filed: 05/11/2007
• Issued: 11/09/2010
• Est. Priority Date: 10/04/2005
• Status: Active Grant

• Current Assignee: Tomophase Corporation
• Original Assignee: Tomophase Corporation
• Inventors: Wang, Feiling, Li, Xiao-Li, Zelenchuk, Alex R.
• Primary Examiner(s): Le; Long V
• Assistant Examiner(s): Brutus; Joel F
• Application Number:
  US11/747,879
• Time in Patent Office: 1,278 Days
• Field of Search: 600/160, 600476-478, 356/345, 356/349
• US Class Current: 600/473
• CPC Class Codes: A61B 1/2676 Bronchoscopes
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 18/22 the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2018/00541 Lung or bronchi
• CPC Class Codes: A61B 2018/2065 Multiwave; Wavelength mixing, e.g. using four or more wavelengths
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body

Abstract

Systems, apparatus and techniques for non-invasive optical probing of various substances, and systems, apparatus and techniques for detecting, diagnosing and treating a disease in lungs and other organs using the non-invasive optical probing, including mapping physiological functions of tissues in lungs and other organs.

Claims

1. A method for optically measuring blood in lung, comprising:

directing to a target area of a lung light in two spectral bands centered at two different wavelengths at which oxygenated blood and the de-oxygenated blood in the target area possess distinctively different absorption characteristics, wherein the two different wavelengths are selected to be located respectively at a lower side and upper side of a light wavelength at which absorption of light by the oxygenated blood equals absorption of light by the de-oxygenated blood;

measuring reflection of the light from the target area of the lung in the two spectral bands centered at the two different wavelengths to obtain optical images of the target area of the lung at different depths from a surface of the target area; and

processing the obtained optical images to extract information on an oxygen exchange state in blood present at the target area of the lung to produce a map of the oxygen exchange state in blood at different depths at each location where the light enters the target area.

2. The method as in claim 1, comprising:

scanning the light in the two spectral bands centered at two different wavelengths along a scanning line to obtain an optical image of a slice of the tissue defined by the scanning line and a depth of penetration of the light into the lung; and

obtaining the information on the oxygen exchange state in blood at different regions in the slice of the tissue from the optical images to form a two dimensional map of the oxygen exchange state of the slice of the tissue.

3. The method as in claim 1, comprising:

scanning the light in the two spectral bands centered at two different wavelengths along a plurality of parallel scanning lines to obtain an optical image of each slice of the tissue defined by a respective scanning line and a depth of penetration of the light into the lung; and

obtaining the information on the oxygen exchange state in blood at different regions in each of the slices of the tissue to form a three dimensional map of the oxygen exchange state of the lung.

4. The method as in claim 1, wherein:

one of the two spectral bands ranges from 650 nm to 800 nm and the other of the two spectral bands ranges from 850 nm to 1000 nm.

5. The method as in claim 1, wherein:

combining and guiding optical radiation from two light sources that emit light at the two different spectral bands, respectively, towards the target area through a common optical waveguide;

reflecting a first portion of the combined radiation away from the target area at a location near the target area away from the target area before the first portion reaches the target area while directing a second portion of the combined radiation to reach the target area;

using a reflection of the second portion from the target area to produce a reflected second portion that spatially overlaps and co-propagates with the first portion at the location where the first portion is reflected;

collecting and guiding at least part of the reflected first portion and at least part of the reflected second portion from the target area towards a detection module through the common optical waveguide;

separating the light into the two beams in two paths in the two spectral bands, respectively, before sending the two beams to the detection module; and

detecting the two beams at the detection module to obtain the optical images.

6. The method as in claim 5, comprising:

controlling the reflected first portion to propagate inside the common waveguide in a first propagation mode and the reflected second portion to propagate inside the common waveguide in a second propagation mode that is different from the first propagation mode.

7. The method as in claim 6, wherein the first propagation mode is a first polarization mode of the common waveguide and the second propagation mode is the second polarization mode different from the first polarization mode of the common waveguide.

8. The method as in claim 5, comprising:

controlling the reflected first portion and the reflected second portion to propagate inside the common waveguide in a common propagation mode.

9. The method as in claim 5, comprising:

producing a delay between the reflected first and second portions; and

modulating the relative delay between the reflected first portion and the reflected second portion to measure a variation in power of light.

10. A method for optically measuring blood in lung, comprising:

combining and guiding optical radiation from two light sources, that emit light at two different spectral bands centered at two different wavelengths at which oxygenated blood and de-oxygenated blood in a target area of a lung possess distinctively different absorption characteristics, towards the target area through a common optical waveguide wherein selecting the two wavelengths to be respectively at a lower side and upper side of a light wavelength at which absorption of light by the oxygenated blood equals absorption of light by the de-oxygenated blood;

reflecting a first portion of the combined radiation away from the target area at a location near the target area away from the target area before the first portion reaches the target area while directing a second portion of the combined radiation to reach the target area;

using a reflection of the second portion from the target area to produce a reflected second portion that spatially overlaps and co-propagates with the first portion at the location where the first portion is reflected;

collecting and guiding at least part of the reflected first portion and at least part of the reflected second portion from the target area towards a detection module through the common optical waveguide;

separating the light into the two beams in two paths in the two spectral bands, respectively, before sending the two beams to the detection module;

detecting two beams at the detection module to obtain the optical images of the target area of the lung at different depths from a surface of the target area; and

processing the obtained optical images to extract information on an oxygen exchange state in blood present at the target area of the lung to produce a map of the oxygen exchange state in blood at different depths at each location where the light enters the target area.

11. The method as in claim 10, comprising:

scanning the light in the two spectral bands centered at two different wavelengths along a scanning line to obtain an optical image of a slice of the tissue defined by the scanning line and a depth of penetration of the light into the lung; and

obtaining the information on the oxygen exchange state in blood at different regions in the slice of the tissue from the optical images to form a two dimensional map of the oxygen exchange state of the slice of the tissue.

12. A device for optically measuring blood in lung, comprising:

two light sources, that emit light at two different spectral bands centered at two different wavelengths at which oxygenated blood and de-oxygenated blood in a target area of a lung possess distinctively different absorption characteristics wherein the two light sources are configured so that the two different wavelengths are respectively at a lower side and upper side of a light wavelength at which absorption of light by the oxygenated blood equals absorption of light by the de-oxygenated blood;

a waveguide to receive and guide the radiation from the two light sources as a probe beam;

a probe head coupled to the waveguide to receive the probe beam and to reflect a first portion of the probe beam back to the waveguide and direct a second portion of the probe beam to the target area of the lung, the probe head configured to overlap reflection of the second portion from the target area with the first portion and to export to the waveguide the reflection as a reflected second portion;

an optical delay device coupled to the waveguide to receive the first portion and the reflected second portion to produce a variable relative phase delay between the first portion and the reflected second portion;

a detection module to receive light of the first portion and the reflected second portion from the optical delay device and to obtain the optical images of the target area of the lung at different depths from a surface of the target area from the received light; and

a processor to process the obtained optical images to extract information on an oxygen exchange state in blood present at the target area of the lung to produce a map of the oxygen exchange state in blood at different depths at each location where the light enters the target area.

13. The device as in claim 12, wherein:

one of the two spectral bands ranges from 650 nm to 800 nm and the other of the two spectral bands ranges from 850 nm to 1000 nm.

14. The device as in claim 12, comprising:

a head scanning mechanism to scan the optical head relative to the target area of the lung to scan the probe beam in the two spectral bands centered at two different wavelengths along a scanning line to obtain an optical image of a slice of the tissue defined by the scanning line and a depth of penetration of the light into the lung; and

wherein the processor is configured to obtain the information on the oxygen exchange state in blood at different regions in the slice of the tissue from the optical images to form a two dimensional map of the oxygen exchange state of the slice of the tissue.