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Simultaneous aspirator and dispenser for multiwell plates and similar devices

  • US 7,832,291 B2
  • Filed: 07/15/2009
  • Issued: 11/16/2010
  • Est. Priority Date: 11/17/2006
  • Status: Expired due to Fees
First Claim
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1. A method of making a measurement of binding affinity of a sample, comprising the steps of:

  • introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor;

    making a measurement of the change in the shift in peak wavelength value as a function of time (kon) from the well as the sample is introduced into the well;

    simultaneously dispensing the sample to the well and aspirating the sample from the well and measuring the change in the shift in peak wavelength value as a function of time (koff) during the simultaneous dispensing and aspirating,calculating an equilibrium association constant or an equilibrium dissociation constant for the sample from the values of kon and koff.

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