Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
First Claim
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1. A stent, the stent having a body comprising a plurality of members, the plurality of members including struts and connectors, the body comprising:
- a first region, the first region comprising a first plurality of struts arranged in a plurality of circumferential bands, longitudinally adjacent bands being engaged by connectors, each strut defining a first plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a first density, each coating retainer having a depth, width, and length and having a first volume, each first coating retainer having a first volume of a first therapeutic agent, the first volume of first therapeutic agent equal to the first volume of the coating retainers, the first plurality of coating retainers eluting a first total volume of a first therapeutic agent; and
a second region longitudinally adjacent to the first region, the second region comprising a second plurality of struts arranged in a plurality of circumferential bands, longitudinally adjacent bands being engaged by connectors, each strut defining a second plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a second density, each coating retainer having a depth, width, and length and having a second volume, each coating retainer having a second volume of a second therapeutic agent, the second volume of second therapeutic agent equal to the second volume of the second coating retainers, the plurality of second coating retainers eluting a second total volume of a second therapeutic agent; and
a side branch, the side branch in an expanded state extending at an angle to the body of the stent, the side branch comprising a third plurality of struts, each strut defining a plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a third density, each coating retainer having a depth, width, and length;
wherein the first density is greater than the second density and the second density is greater than the third density, the first total volume of therapeutic agent is greater than the second total volume of therapeutic agent, and the first volume of each of the first plurality of coating retainers is greater than the second volume each of the second plurality of coating retainers.
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Abstract
The invention is directed to a stent that delivers multiple therapeutic regimens from different regions of the stent.
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Citations
19 Claims
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1. A stent, the stent having a body comprising a plurality of members, the plurality of members including struts and connectors, the body comprising:
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a first region, the first region comprising a first plurality of struts arranged in a plurality of circumferential bands, longitudinally adjacent bands being engaged by connectors, each strut defining a first plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a first density, each coating retainer having a depth, width, and length and having a first volume, each first coating retainer having a first volume of a first therapeutic agent, the first volume of first therapeutic agent equal to the first volume of the coating retainers, the first plurality of coating retainers eluting a first total volume of a first therapeutic agent; and a second region longitudinally adjacent to the first region, the second region comprising a second plurality of struts arranged in a plurality of circumferential bands, longitudinally adjacent bands being engaged by connectors, each strut defining a second plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a second density, each coating retainer having a depth, width, and length and having a second volume, each coating retainer having a second volume of a second therapeutic agent, the second volume of second therapeutic agent equal to the second volume of the second coating retainers, the plurality of second coating retainers eluting a second total volume of a second therapeutic agent; and a side branch, the side branch in an expanded state extending at an angle to the body of the stent, the side branch comprising a third plurality of struts, each strut defining a plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a third density, each coating retainer having a depth, width, and length; wherein the first density is greater than the second density and the second density is greater than the third density, the first total volume of therapeutic agent is greater than the second total volume of therapeutic agent, and the first volume of each of the first plurality of coating retainers is greater than the second volume each of the second plurality of coating retainers. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A bifurcated stent, the bifurcated stent having a tubular body comprising a plurality of members, the plurality of members comprising a plurality of struts and connectors, the tubular body comprising:
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a first region, the first region having a first plurality of struts, the plurality of struts connected one to another by turns and arranged in circumferential bands adjacent circumferential bands engaged by connectors, each strut defining a first plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a first density and eluting a first local concentration of therapeutic agent, the each coating retainer having a first size; and a second region longitudinally adjacent to the first region, the second region having a second plurality of struts and a side branch, the second plurality of struts connected one to another by turns and arranged in circumferential bands, adjacent circumferential bands engaged by connectors, each strut defining a second plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a second density and eluting a second local concentration of therapeutic agent, each coating retainer having a second size, the side branch comprising a plurality of struts, the plurality of struts extending at an angle to the tubular body of the bifurcated stent when the side branch is in an expanded state; wherein the first density is greater than the second density, the first local concentration is greater than the second local concentration, and the first size is equal to the second size.
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8. A bifurcated stent having a tubular body comprising a first section, a second section, and a third section, the first section forming a first end region of the bifurcated stent and the third section forming a second end region of the bifurcated stent,
the first section comprising a plurality of struts engaged one to another by turns, each strut defining a first number of coating retainers, all of the coating retainers defined by a strut have a first density, the plurality of struts arranged in circumferential bands, adjacent circumferential bands being engaged one to another by connectors; -
the second section comprising a plurality of struts engaged one to another by turns, each strut defining a second number of coating retainers, all of the coating retainers defined by a strut have a second density, the second section further comprising a side branch, the side branch extending at an angle to the tubular body of the bifurcated stent when the side branch is in an expanded state, the side branch comprising a plurality of struts, each strut defining a third number of coating retainers, all of the coating retainers defined by a strut have a third density; the third section comprising a plurality of struts engaged one to another by turns, each strut defining a fourth number of coating retainers, all of the coating retainers defined by a strut have a fourth density, the plurality of struts arranged in circumferential bands, adjacent circumferential bands being engaged one to another by connectors; wherein the first number of coating retainers and the fourth number of coating retainers are the same, wherein the first density and the fourth density are the same, and wherein the third number of coating retainers is different than the first number of coating retainers. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification