Anti-IL-6 antibodies, compositions, methods and uses
First Claim
1. An isolated host cell comprising an isolated nucleic acid molecule comprising a nucleotide sequence that encodes a heavy chain antibody variable region and a nucleic acid molecule comprising a nucleotide sequence that encodes a light chain antibody variable region, wherein said heavy chain variable region comprises CDR1, CDR2 and CDR3 amino acid sequences selected from SEQ ID NOS:
- 1-3 respectively and said light chain variable region comprises CDR1, CDR2 and CDR3 amino acid sequences selected from SEQ ID NOS;
4-6, respectively, wherein the antibody binds IL-6.
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Accused Products
Abstract
The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
70 Citations
4 Claims
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1. An isolated host cell comprising an isolated nucleic acid molecule comprising a nucleotide sequence that encodes a heavy chain antibody variable region and a nucleic acid molecule comprising a nucleotide sequence that encodes a light chain antibody variable region, wherein said heavy chain variable region comprises CDR1, CDR2 and CDR3 amino acid sequences selected from SEQ ID NOS:
- 1-3 respectively and said light chain variable region comprises CDR1, CDR2 and CDR3 amino acid sequences selected from SEQ ID NOS;
4-6, respectively, wherein the antibody binds IL-6. - View Dependent Claims (2, 3, 4)
- 1-3 respectively and said light chain variable region comprises CDR1, CDR2 and CDR3 amino acid sequences selected from SEQ ID NOS;
Specification