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Toxin peptide therapeutic agents

  • US 7,833,979 B2
  • Filed: 04/17/2006
  • Issued: 11/16/2010
  • Est. Priority Date: 04/22/2005
  • Status: Active Grant
First Claim
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1. A composition of matter of the formula
(X1)a—

  • (F1)d—

    (X2)b—

    (F2)e—

    (X3)cor multimers thereof, wherein;

    F1 and F2 are half-life extending moieties, and d and e are each independently 0 or 1, provided that at least one of d and e is 1;

    X1, X2, and X3 are each independently -(L)f-P-(L)9-, and f and g are each independently 0 or 1;

    P is a ShK peptide analog of no more than about 80 amino acid residues in length, comprising the amino acid sequence of SEQ ID NO;

    914, SEQ ID NO;

    915, SEQ ID NO;

    916, or SEQ ID NO;

    917, and comprising at least two intrapeptide disulfide bonds;

    L is a linker; and

    a, b, and c are each independently 0 or 1, provided that at least one of a, b and c is 1;

    or a physiologically acceptable salt thereof.

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