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Substrates, systems and methods for analyzing materials

  • US 7,834,329 B2
  • Filed: 10/31/2007
  • Issued: 11/16/2010
  • Est. Priority Date: 09/01/2006
  • Status: Active Grant
First Claim
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1. A method of detecting a signal from an analyte, comprising:

  • providing a substrate comprising a first surface and at least a first optical waveguide disposed upon the first surface;

    providing an individual analyte disposed sufficiently proximal to the first surface and external to the waveguide to be illuminated by an evanescent field emanating from the waveguide when light is passed through the waveguide, wherein the individual analyte is immobilized on the first surface such that a signal from the individual analyte is optically resolvable from any other signal from any other analyte immobilized on the first surface and illuminated by the evanescent field;

    directing light through the first waveguide such that the evanescent field from the waveguide illuminates the individual analyte; and

    detecting a signal from the individual analyte.

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