Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media
First Claim
1. A method for optimizing a probe geometry for spectroscopic measurement in a turbid medium, the method comprising:
- using a computer programmed to perform the following steps;
(a) selecting a probe geometry comprising at least one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium;
(b) performing a simulation of a light transport model with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values that would be measured by the probe geometry for each set of input optical property values;
(c) providing the measured optical parameter values as input to an inversion algorithm that produces optical properties corresponding to the measured optical parameter values generated by the simulation of the light transport model as output;
(d) comparing the optical properties produced by the inversion algorithm with the plurality of sets of optical properties known to correspond to the measured optical parameter values and determining a degree of matching between the produced and known optical properties;
(e) repeating steps (b)-(d) for a plurality of additional probe geometries, wherein each additional probe geometry differs from the probe geometry of step (a) in at least one property selected from the group consisting of a quantity of collecting entities, a diameter of at least one collecting entity, a linear distance between the emitting entity and the collecting entity, and combinations thereof, wherein repeating steps (b)-(d) comprises, at each iteration, applying an optimization algorithm to select a probe geometry such that the resulting degree of matching will converge to an optimum value; and
(f) selecting from among the different probe geometries, an optimal geometry for the turbid medium based on the degree of matching determined for each geometry in step (d).
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Accused Products
Abstract
Methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium are provided. A probe geometry comprising one emitting entity and at least on collecting entity is selected. A simulation is performed to generate optical parameter values measured by the probe geometry. The measured optical parameter values are input to an inversion algorithm to produce corresponding optical properties as output. The produced optical properties are compared with known optical properties known and a degree of matching between the produced optical properties and the known optical properties is determined. The simulation and inversion steps are repeated for a plurality of additional probe geometries, each differing in at least one property. An optimization algorithm is applied at each iteration to select an optimal probe geometry.
53 Citations
22 Claims
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1. A method for optimizing a probe geometry for spectroscopic measurement in a turbid medium, the method comprising:
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using a computer programmed to perform the following steps; (a) selecting a probe geometry comprising at least one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium; (b) performing a simulation of a light transport model with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values that would be measured by the probe geometry for each set of input optical property values; (c) providing the measured optical parameter values as input to an inversion algorithm that produces optical properties corresponding to the measured optical parameter values generated by the simulation of the light transport model as output; (d) comparing the optical properties produced by the inversion algorithm with the plurality of sets of optical properties known to correspond to the measured optical parameter values and determining a degree of matching between the produced and known optical properties; (e) repeating steps (b)-(d) for a plurality of additional probe geometries, wherein each additional probe geometry differs from the probe geometry of step (a) in at least one property selected from the group consisting of a quantity of collecting entities, a diameter of at least one collecting entity, a linear distance between the emitting entity and the collecting entity, and combinations thereof, wherein repeating steps (b)-(d) comprises, at each iteration, applying an optimization algorithm to select a probe geometry such that the resulting degree of matching will converge to an optimum value; and (f) selecting from among the different probe geometries, an optimal geometry for the turbid medium based on the degree of matching determined for each geometry in step (d). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A system for selecting an optimal geometry for a probe for spectroscopic measurement in turbid media, the system comprising:
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at least one processor programmed to implement; (a) a light transport model configured to receive as inputs a probe geometry and a plurality of sets of optical properties of a turbid medium and configured to produce as output optical parameter values that would be measured by the probe geometry for each set of input optical properties; (b) an objective function configured to implement an inversion algorithm that is configured to receive as input the measured optical parameter values, configured to produce corresponding optical properties, configured to compare the optical properties produced by the inversion algorithm with the plurality of sets of optical properties known to correspond to the measured optical parameter values, and configured to determine a degree of matching between the produced and known optical properties for the given probe geometry, wherein the light transport model and the inversion algorithm are adapted to test a plurality of different probe geometries and wherein the inversion algorithm is configured to determine a degree of matching between the produced and known optical properties for each geometry; and (c) a probe selector configured to select one of the geometries as an optimal geometry for the turbid medium based the degree of matching associated with the selected geometry. - View Dependent Claims (20, 21)
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22. A computer program product comprising computer executable instructions embodied in a non-transitory computer readable medium for performing steps comprising:
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(a) selecting a probe geometry comprising at least one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium; (b) performing a simulation of a light transport model with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values that would be measured by the probe geometry for each set of input optical property values; (c) providing the measured optical parameter values as input to an inversion algorithm that produces optical properties corresponding to the measured optical parameter values generated by the simulation of the light transport model as output; (d) comparing the optical properties produced by the inversion algorithm with the plurality of sets of optical properties known to correspond to the measured optical parameter values and determining a degree of matching between the produced and known optical properties; (e) repeating steps (b)-(d) for a plurality of additional probe geometries, wherein each additional probe geometry differs from the probe geometry of step (a) in at least one property selected from the group consisting of a quantity of collecting entities, a diameter of at least one emitting or collecting entity, a linear distance between the emitting and collecting entities, and combinations thereof, wherein repeating steps (b)-(d) comprises, at each iteration, applying an optimization algorithm to select a probe geometry such that the resulting degree of matching will converge to an optimum value; and (f) selecting, from among the different probe geometries, an optimal geometry for the turbid medium based on the degree of matching determined for each geometry in step (d).
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Specification