Medical treatment system using biological regulation function alternate, cardiac pacing system based on the medical treatment system, blood pressure regulating system, and cardiac disease treating system

• US 7,835,791 B2
• Filed: 08/05/2002
• Issued: 11/16/2010
• Est. Priority Date: 08/05/2002
• Status: Active Grant

• Current Assignee: Fujikin Incorporated, National Cerebral And Cardiovascular Center
• Original Assignee: Fujikin Incorporated, National Cerebral And Cardiovascular Center
• Inventors: Sugimachi, Masaru, Sunagawa, Kenji, Sato, Takayuki
• Primary Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US10/523,539
• Publication Number:
  US 20050288718A1
• Time in Patent Office: 3,025 Days
• Field of Search: 607/17
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

A medical treating system based on biological activities characterized by biological activity sensing means for sensing biological activity information produced by biological activities and outputting a biological activity signal, calculating means for receiving, analyzing, and processing the biological activity signals from the biological activity sensing means, calculating an organism stimulation signal, and outputting the organism stimulation signal, and organism stimulating means for receiving the organism stimulation signal calculated by the calculating means and stimulating an organism according to the organism stimulation signal. A cardiac pacing system based on the treating system, a blood pressure regulating system, and a cardiac disease treating system are also disclosed.

Claims

1. A system to treat diseases based on biological activities, comprising:

a) at least one biological activity sensing means which senses biological activity information issued by biological activities, and outputs a plurality of input biosignals;

b) a calculating means which receives the input biosignals, calculates a transfer function by computing a Fourier transform of normal-activity biosignals from normal biological activities, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a plurality of stimulation signals for stimulation of an organism using a convolution integral between the input biosignals and the impulse response, and outputs the stimulation signals for stimulation of the organism; and

c) an organism stimulating means which receives the stimulation signals, and stimulates the organism based on the stimulation signals.

2. The system of claim 1, wherein the biological activity sensing means is selected from the group consisting of electrodes and pressure sensors.

3. The system of claim 1, wherein the biological activity sensing means senses biological activity information selected from the group consisting of sympathetic nerve activities, parasympathetic nerve activities, blood flow, blood pressure, body temperature, electrocardiogram, electroencephalogram, and various biochemical markers.

4. The system of claim 1, wherein the organism stimulating means is selected from the group consisting of electrical stimulation means;

and stimulation means with the use of devices for drug administration.

5. The system of claim 1, wherein the calculating means comprises:

at least one amplifier to amplify the input biosignals;

at least one analog-to-digital converter, to convert the input biosignals from analog signals to digital signals; and

at least one analyzer to calculate stimulation signals to be transferred to the organism stimulating means.

6. A system to treat diseases based on biological activities, comprising:

a) at least one biological activity sensing means which senses biological activity information issued by biological activities, and outputs a plurality of input biosignals;

b) a calculating means which receives the input biosignals, calculates a transfer function by computing a Fourier transform of normal-activity biosignals from normal biological activities, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a plurality of stimulation signals for stimulation of an organism using a convolution integral between the input biosignals and the impulse response, and outputs the stimulation signals for stimulation of the organism; and

c) an organism stimulating means which receives the stimulation signals calculated by the calculating means, and stimulates the organism based on the stimulation signals;

wherein the calculating means includes discriminating means which determine whether the input biosignals are caused by normal biological activities or by abnormal biological activities;

wherein the calculating means does not output the stimulation signals when the input biosignals are determined to be caused by normal biological activities; and

wherein the calculating means outputs the stimulation signals when the input biosignals are determined to be caused by abnormal biological activities.

7. A method of treating diseases based on biological activities, comprising the steps of:

a) calculating a transfer function by computing a Fourier transform of normal-activity biosignals from normal biological activities and calculating at least one impulse response by computing an inverse Fourier transform of the transfer function;

b) sensing biological activity information issued by biological activities, and outputting a plurality of input biosignals based on the biological activity information;

c) calculating a plurality of stimulation signals for stimulation of an organism using a convolution integral between the impulse response and the input biosignals, comprising the substep of discriminating whether the input biosignals are caused by normal biological activities or by abnormal biological activities; and

d) outputting the stimulation signals for stimulation of the organism only if the input biosignals are determined to be caused by abnormal biological activities.

8. The method of claim 7, further comprising, after step d), the steps of:

e) receiving the stimulation signals output in step d); and

f) stimulating the organism based on the stimulation signals output in step d).

9. The method of claim 8, wherein step f) comprises stimulation selected from the group consisting of electrical stimulation;

and stimulation with the use of devices for drug administration.

10. The method of claim 7, wherein step b) is performed using a device selected from the group consisting of electrodes and pressure sensors.

11. The method of claim 7, wherein, step b) senses biological activity information selected from the group consisting of sympathetic nerve activities, parasympathetic nerve activities, blood flow, blood pressure, body temperature, electrocardiogram, electroencephalogram, and various biochemical markers.

12. The method of claim 7, wherein step c) is performed using a device that comprises:

at least one amplifier to amplify the input biosignals;

at least one analog-to-digital converter, to convert the input biosignals from analog signals to digital signals; and

at least one analyzer to calculate the stimulation signals.