Devices and methods for facilitating controlled bone growth or repair

• US 7,837,735 B2
• Filed: 03/30/2004
• Issued: 11/23/2010
• Est. Priority Date: 12/14/2000
• Status: Active Grant

• Current Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Original Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Inventors: Malone, David G.
• Primary Examiner(s): Stewart; Alvin J.
• Application Number:
  US10/812,837
• Publication Number:
  US 20040225360A1
• Time in Patent Office: 2,429 Days
• Field of Search: 623 1711- 1716, 623/16.11, 623/18.11
• US Class Current: 623/17.16
• CPC Class Codes: A61B 17/7064 Devices acting on, attached to, or simulating the effect of, vertebral facets; Tools therefor
• CPC Class Codes: A61B 17/72 Intramedullary pins, nails or other devices A61B17/744 takes precedence
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/8685 comprising multiple separate parts
• CPC Class Codes: A61F 2/30744 End caps, e.g. for closing an endoprosthetic cavity
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/3662 Femoral shafts
• CPC Class Codes: A61F 2/446 having a circular or elliptical cross-section substantially parallel to the axis of the spine, e.g. cylinders or frustocones
• CPC Class Codes: A61F 2/4611 of spinal prostheses
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30028 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2002/30115 circular-O-shaped
• CPC Class Codes: A61F 2002/30143 hexagonal
• CPC Class Codes: A61F 2002/30153 rectangular
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30364 Rotation about the common longitudinal axis
• CPC Class Codes: A61F 2002/30593 hollow
• CPC Class Codes: A61F 2002/30604 modular
• CPC Class Codes: A61F 2002/30616 : Sets comprising a plurality of prosthetic parts of different sizes or orientations
• CPC Class Codes: A61F 2002/30677 : Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30787 : inclined obliquely with respect to each other
• CPC Class Codes: A61F 2002/3085 : with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
• CPC Class Codes: A61F 2002/30904 : serrated profile, i.e. saw-toothed
• CPC Class Codes: A61F 2002/30932 : for retarding or preventing ingrowth of bone tissue
• CPC Class Codes: A61F 2002/3611 : Heads or epiphyseal parts of femur
• CPC Class Codes: A61F 2002/368 : with lateral apertures, bores, holes or openings, e.g. for reducing the mass, for receiving fixation screws or for communicating with the inside of a hollow shaft
• CPC Class Codes: A61F 2002/448 : comprising multiple adjacent spinal implants within the same intervertebral space or within the same vertebra, e.g. comprising two adjacent spinal implants
• CPC Class Codes: A61F 2220/0033 : made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2230/0006 : circular
• CPC Class Codes: A61F 2230/0017 : Angular shapes
• CPC Class Codes: A61F 2230/0019 : rectangular
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2310/00017 : Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 : Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Abstract

Bone implantable devices and methodologies permit careful application of biologically active substances and management of bone growth processes. The device includes a body defining a carrier receiving area for locating adjacent bone. Carrier material is located in the carrier receiving area. Substance is delivered onto carrier material through a port. A pathway delivers substance from the carrier receiving area to the bone surface. The body may be in the form of a spinal fusion cage, facet fusion screw, artificial joint, bone fixation plate, interbody graft, IM nail, hip stem, or other bone-to-bone appliances or bone-to-device appliances. In use, carrier is installed in the carrier receiving area of the device. The device is then implanted adjacent a bone. The substance is applied to the carrier for subsequent delivery to the bone. By doping carrier material after device implantation, inadvertent contact of the substance with non-target bone is more easily eliminated.

Claims

1. An interbody spine fusion cage for fusing adjacent vertebrae, said spinal fusion cage comprising:

a cage body defining an outside surface;

a carrier receiving area defined by said cage body;

an un-doped carrier material loaded in said carrier receiving area;

a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material;

a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure;

an end cap on an end of said cage body for enclosing said carrier receiving area;

wherein said port is located in said end cap; and

further comprising;

a plug in said port adapted to be penetrated by a delivery device.

2. An interbody spine fusion cage according to claim 1 wherein:

said delivery device is a syringe.

3. An implantable device for locating within a body, said implantable device comprising:

a body defining an outside surface;

a carrier receiving area defined by said body;

an un-doped carrier material loaded in said carrier receiving area;

a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material;

a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure;

a plug in said port adapted to be penetrated by a syringe; and

the interbody spine fusion cage further comprising;

a substantially solid end cap on an end of said cage body wherein said end cap encloses said carrier receiving area; and

wherein said port is located in said end cap.

4. An interbody spine fusion cage for fusing adjacent vertebrae, said spinal fusion cage comprising:

a cage body defining an outside surface;

a carrier receiving area defined by said cage body;

an un-doped collagen carrier material loaded in said carrier receiving area;

a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material;

a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure;

a plug in said port adapted to be penetrated by a syringe;

a substantially solid end cap on an end of said cage body wherein said end cap encloses said carrier receiving area; and

wherein said port is located in said end cap.

5. An implantable device for locating within a body, said implantable device comprising:

a body defining an outside surface;

a carrier receiving area defined by said body;

an un-doped collagen carrier material loaded in said carrier receiving area;

a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said un-doped carrier material;

a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure;

a plug in said port adapted to be penetrated by a syringe;

a substantially solid end cap on an end of said cage body wherein

said end cap encloses said carrier receiving area; and

wherein said port is located in said end cap.

6. A bone implantable device for locating adjacent a target bone structure, said bone implantable device comprising:

a body defining an outside surface;

a carrier receiving area defined by said body;

a pre-loaded collagen carrier material in said carrier receiving area, said pre-loaded collagen carrier material comprising a biologically active substance;

a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to the target bone structure;

the interbody spine fusion cage further comprising;

a substantially solid end cap on an end of said cage body wherein

said end cap encloses said carrier receiving area; and

wherein a port is located in said end cap;

a plug in said port, said plug adapted to be penetrated by a syringe.

7. A bone implantable device for locating adjacent a target bone structure, said bone implantable device comprising:

a body defining an outside surface;

a carrier receiving area defined by said body;

a pre-loaded sponge material in said carrier receiving area, said pre-loaded sponge material comprising a biologically active substance;

a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to the target bone structure;

the interbody spine fusion cage further comprising;

a substantially solid end cap on an end of said cage body wherein said end cap encloses said carrier receiving area; and

wherein a port is located in said end cap;

a plug in said port, said plug adapted to be penetrated by a syringe.