Two piece cancellous construct for cartilage repair

• US 7,837,740 B2
• Filed: 01/24/2007
• Issued: 11/23/2010
• Est. Priority Date: 01/24/2007
• Status: Active Grant

• Current Assignee: Musculoskeletal Transplant Foundatio, Musculoskeletal Transplant Foundation
• Original Assignee: Musculoskeletal Transplant Foundation
• Inventors: Semler, Eric J., Yannariello-Brown, Judith I., Truncale, Katherine G., Callahan, Alex B.
• Primary Examiner(s): Snow; Bruce E
• Assistant Examiner(s): HOBAN, MELISSA A
• Application Number:
  US11/657,042
• Publication Number:
  US 20080255676A1
• Time in Patent Office: 1,399 Days
• Field of Search: 623/23.51, 623/23.48, 623/23.61, 623/23.63
• US Class Current: 623/23.63
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/2839 Bone plugs or bone graft dowels
• CPC Class Codes: A61F 2002/30057 made from both cortical and cancellous adjacent parts
• CPC Class Codes: A61F 2002/30059 differing in bone mineralization, e.g. made from both mineralized and demineralized adjacent parts
• CPC Class Codes: A61F 2002/30225 Flat cylinders, i.e. discs
• CPC Class Codes: A61F 2002/30227 arched, domed or vaulted
• CPC Class Codes: A61F 2002/30233 Stepped cylinders, i.e. having discrete diameter changes
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30327 differing in diameter
• CPC Class Codes: A61F 2002/30354 Cylindrically-shaped protrusion and recess, e.g. cylinder of circular basis
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2002/30459 stapled
• CPC Class Codes: A61F 2002/30461 sutured, ligatured or stitched
• CPC Class Codes: A61F 2002/30492 using a locking pin
• CPC Class Codes: A61F 2002/30604 modular
• CPC Class Codes: A61F 2002/30759 : Mosaicplasty, i.e. using a plurality of individual cartilage plugs for filling a substantial cartilage defect
• CPC Class Codes: A61F 2002/30762 : Means for culturing cartilage
• CPC Class Codes: A61F 2002/30764 : Cartilage harvest sites
• CPC Class Codes: A61F 2002/30772 : Apertures or holes, e.g. of circular cross section
• CPC Class Codes: A61F 2002/30785 : parallel
• CPC Class Codes: A61F 2002/30789 : perpendicular with respect to each other
• CPC Class Codes: A61F 2002/30795 : Blind bores, e.g. of circular cross-section
• CPC Class Codes: A61F 2002/30932 : for retarding or preventing ingrowth of bone tissue
• CPC Class Codes: A61F 2002/4635 : using minimally invasive surgery
• CPC Class Codes: A61F 2002/4646 : Devices for cleaning bone graft
• CPC Class Codes: A61F 2002/4649 : Bone graft or bone dowel harvest sites
• CPC Class Codes: A61F 2220/0025 : Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2220/0033 : made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2220/005 : using adhesives
• CPC Class Codes: A61F 2220/0066 : stapled
• CPC Class Codes: A61F 2220/0075 : sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2250/0039 : differing in diameter
• CPC Class Codes: A61F 2310/00365 : Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 2300/414 : Growth factors
• CPC Class Codes: A61L 2300/64 : Animal cells
• CPC Class Codes: A61L 2430/06 : for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/3608 : Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3654 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/38 : containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/54 : Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.

Claims

1. A construct for cartilage repair, comprising:

a cap member formed from bone, said cap member including a stem having a longitudinal axis, which defines an axial direction, and a radial bore extending generally transversely into said stem from an exterior surface thereof, and a top section attached to one end of said stem and extending radially outward therefrom, said top section being substantially demineralized, whereby said top section has an elastic quality;

a base member at least partially formed from mineralized bone, said base member including a blind bore extending in said axial direction from one end of said base member toward an opposite end thereof and sized and shaped so as to receive said stem of said cap member, said blind bore having a bottom surface intermediate said one end of said base member and said opposite end of said base member, said one end of said base member including an annular surface surrounding said blind bore and sized and shaped so as to support said top section of said cap member when said stem of said cap member is received within said blind bore of said base member, and at least one lateral bore intermediate said annular surface and said bottom surface of said blind bore, said at least one lateral bore extending generally transversely from an exterior wall of said base member to said blind bore and being alignable with said radial bore of said stem of said cap member when said stem is received in said blind bore of said base member; and

fastening means for fastening said cap member to said base member when said stem is received within said blind bore of said base member and when said radial bore and said at least one lateral bore are aligned.

2. The construct of claim 1, wherein said stem includes a free end opposite said one end of said stem.

3. The construct of claim 2, wherein said radial bore of said stem is positioned intermediate said free end of said stem and said one end of said stem.

4. The construct of claim 1, wherein said at least one lateral bore includes a first lateral bore located on one side of said base member and a second lateral bore located on an opposite side of said base member in coaxial alignment with said first lateral bore, said radial bore of said stem being alignable with said first and second lateral bores of said base member when said stem is received in said blind bore of said base member.

5. The construct of claim 4, wherein said fastening means includes a pin sized and shaped so as to be insertable into said first and second lateral bores of said base member and said radial bore of said stem, when said stem is received in said blind bore of said base member such that said radial bore of said stem is in coaxial alignment with said first and second lateral bores of said base member.

6. The construct of claim 5, wherein said pin is formed from allograft bone.