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Evaluation method of organic or bio-conjugation on nanoparticles using imaging of time-of-flight secondary ion mass spectrometry

  • US 7,838,257 B2
  • Filed: 04/29/2008
  • Issued: 11/23/2010
  • Est. Priority Date: 12/11/2007
  • Status: Active Grant
First Claim
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1. A method of evaluating conjugation between materials using TOF-SIMS (Time-Of-Flight Secondary Ion Mass Spectrometry) comprising the steps of:

  • a) forming a spontaneous pattern on a substrate with a mixture comprising nanoparticles and a conjugation material selected from organic, bio or inorganic material;

    b) obtaining an ion detection pattern from said conjugation material and said nanoparticles, respectively, depending on their position on the substrate by using TOF-SIMS; and

    c) determining whether the conjugation is formed between said conjugation material and said nanoparticles by comparing the ion detection pattern of said conjugation material with the ion detection pattern of said nanoparticles.

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