Device for chemical and biochemical reactions using photo-generated reagents
First Claim
1. A device for selectively converting photogenerated reagent precursors to freely diffusible photogenerated reagents in solution for effecting a chemical reaction comprising:
- a) a substrate comprising at least one solid surface containing a plurality of fluidly isolatable reaction sites, wherein said fluidly isolatable reaction sites spatially isolate individual reaction sites and prevent diffusion of reagents between adjacent reaction sites, wherein said reaction sites comprise one or more reagents and contain a solution of at least one photogenerated reagent precursor; and
b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator comprising a digital micromirror device comprising a plurality of micromirrors to form an irradiation pattern, wherein said irradiation pattern selectively irradiates a plurality of reaction sites without use of a photolithographic mask thereby converting the photogenerated reagent precursors in said solution to freely diffusible photogenerated reagents thereby effecting a chemical reaction.
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Abstract
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for selectively converting photogenerated reagent precursors to photogenerated reagents comprising a substrate comprising at least one solid surface containing a plurality of isolated reaction sites; and an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein the irradiation pattern selectively irradiates a plurality of reaction sites without use of a photolithographic mask. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
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Citations
8 Claims
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1. A device for selectively converting photogenerated reagent precursors to freely diffusible photogenerated reagents in solution for effecting a chemical reaction comprising:
- a) a substrate comprising at least one solid surface containing a plurality of fluidly isolatable reaction sites, wherein said fluidly isolatable reaction sites spatially isolate individual reaction sites and prevent diffusion of reagents between adjacent reaction sites, wherein said reaction sites comprise one or more reagents and contain a solution of at least one photogenerated reagent precursor; and
b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator comprising a digital micromirror device comprising a plurality of micromirrors to form an irradiation pattern, wherein said irradiation pattern selectively irradiates a plurality of reaction sites without use of a photolithographic mask thereby converting the photogenerated reagent precursors in said solution to freely diffusible photogenerated reagents thereby effecting a chemical reaction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- a) a substrate comprising at least one solid surface containing a plurality of fluidly isolatable reaction sites, wherein said fluidly isolatable reaction sites spatially isolate individual reaction sites and prevent diffusion of reagents between adjacent reaction sites, wherein said reaction sites comprise one or more reagents and contain a solution of at least one photogenerated reagent precursor; and
Specification