Self-assembly and mineralization of peptide-amphiphile nanofibers

• US 7,838,491 B2
• Filed: 12/08/2008
• Issued: 11/23/2010
• Est. Priority Date: 11/14/2001
• Status: Active Grant

• Current Assignee: Northwestern University
• Original Assignee: Northwestern University
• Inventors: Stupp, Samuel I., Hartgerink, Jeffrey D., Beniash, Elia
• Primary Examiner(s): Gupta; Anish
• Application Number:
  US12/330,468
• Publication Number:
  US 20090156505A1
• Time in Patent Office: 715 Days
• Field of Search: None
• US Class Current: 514/16.7
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 47/6907 the form being a microemulsion, nanoemulsion or micelle
• CPC Class Codes: A61K 47/6919 the form being a ribbon or a tubule cochleate
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C07K 5/101 the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
• CPC Class Codes: C07K 7/06 having 5 to 11 amino acids
• CPC Class Codes: C07K 7/08 having 12 to 20 amino acids gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68

Abstract

Peptide-amphiphilic compositions capable of self-assembly into useful nanostructures.

Claims

1. A method of using a peptide amphiphile composition to control hydroxyapatite crystal growth, said method comprising:

providing a solvent medium with at least one peptide amphiphile composition comprising a peptide component selected from the group consisting of

2. The method of claim 1, wherein micelle assembly is induced by adjusting the pH of said medium to less than about 4.

3. The method of claim 1, wherein the peptide amphiphile has the peptide component is SEQ ID NO:

9 and has a C₁₆ hydrocarbon component.