Biologic replacement for fibrin clot

• US 7,838,630 B2
• Filed: 03/29/2005
• Issued: 11/23/2010
• Est. Priority Date: 06/22/1999
• Status: Active Grant

• Current Assignee: Children's Medical Center Corporation
• Original Assignee: Children's Medical Center Corporation
• Inventors: Murray, Michael F., Murray, Martha M., Marler, Jennifer
• Primary Examiner(s): KAM, CHIH MIN
• Application Number:
  US11/092,992
• Publication Number:
  US 20050261736A1
• Time in Patent Office: 2,065 Days
• Field of Search: 530/356, 623/13.17, 623/14.12, 604/214
• US Class Current: 530/356
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 24/102 Collagen
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/3616 Blood, e.g. platelet-rich plasma
• CPC Class Codes: A61L 27/3645 Connective tissue
• CPC Class Codes: A61L 27/365 Bones
• CPC Class Codes: A61L 27/3654 Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3662 Ligaments, tendons
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3843 Connective tissue
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C08L 89/06 : derived from leather or skin , e.g. gelatin
• CPC Class Codes: Y10S 623/917 : Collagen

Abstract

The invention provides composition and methods for repairing a ruptured anterior cruciate ligament.

Claims

1. A scaffold for repair of an intra-articular tissue defect in an intrasynovial environment comprising a three-dimensional matrix designed to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient'"'"'s joint at the site of the intra-articular tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises plasma.

5. The scaffold as in any one of claims 1, 2, 3, or 4, wherein the scaffold is resistant to degradation by synovial fluid.

6. The scaffold as in any one of claims 1, 2, 3, or 4, wherein said matrix is freeze dried.

7. The scaffold as in any one of claims 1, 2, 3, or 4, further comprising a glycosaminoglycan.

8. The scaffold as in any one of claims 1, 2, 3, or 4, further comprising a growth factor.

9. The scaffold of claim 8, wherein the growth factor is selected from the group consisting of:

epidermal growth factor (EGF);

fibroblast growth factor (FGF);

transforming growth factor (TGF); and

platelet derived growth factor (PDGF).

10. The scaffold as in any one of claims 1, 2, 3, or 4, further comprising a cytokine.

12. The scaffold as in any one of claims 1, 3, or 4, further comprising a platelet.

13. The scaffold as in any one of claims 1, 2, or 4, further comprising a neutralizing agent.

14. The scaffold as in any one of claims 1, 2, 3, or 4, further comprising an extracellular matrix protein.

15. The scaffold of claim 14, wherein the extracellular matrix protein is selected from the group consisting of elastin, laminin, fibronectin and entectin.

16. The scaffold as in any one of claim 1, 2, or 3, wherein said intra-articular tissue defect is a partial or complete tear of a ligament exposed to synovial fluid, and wherein the ligament is an anterior cruciate ligament (ACL).

17. The scaffold as in any one of claim 1, 2, 3, or 4, wherein the intra-articular tissue defect is of the meniscus.

18. The scaffold as in any one of claim 1, 2, 3, or 4, wherein the intra-articular tissue defect is of cartilage.

19. The scaffold as in any one of claims 1, 2, 3, wherein the intra-articular tissue defect is of labrum.

20. The scaffold as in any one of claims 1, 2, 3, wherein the intra-articular tissue defect is of bone.

21. The scaffold as in any one of claims 1, 2, 3, or 4, further comprising a suture or clip.

22. The scaffold as in any one of claims 1, 2, 3, or 4, wherein the scaffold is cross-linked with a crosslinking agent.

23. The scaffold of claim 22, wherein the crosslinking agent is selected from the group consisting of a gluteraldehyde, ethanol, ultraviolet light, and a dehydrothermal agent.

2. A scaffold for repair of an intra-articular tissue defect in an intrasynovial environment comprising a three-dimensional matrix designed to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient'"'"'s joint at the site of the intra-articular tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a platelet.

11. The scaffold as in any one of claims 2, 3, or 4, further comprising plasma.

3. A scaffold for repair of an intra-articular tissue defect in an intrasynovial environment comprising a three-dimensional matrix designed to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient'"'"'s joint at the site of the intra-articular tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a neutralizing agent.

4. A scaffold for repair of an intra-articular tissue defect in an intrasynovial environment comprising a three-dimensional matrix designed to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient'"'"'s joint at the site of the intra-articular tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, wherein said scaffold further comprises plasma, a platelet or a neutralizing agent, and wherein said intra-articular tissue defect is of labrum.