System and method for breaking reentry circuits by cooling cardiac tissue

• US 7,840,264 B1
• Filed: 03/30/2007
• Issued: 11/23/2010
• Est. Priority Date: 08/19/1996
• Status: Expired due to Fees

• Current Assignee: MR3 Medical, LLC
• Original Assignee: MR3 Medical, LLC
• Inventors: Mower, Morton M.
• Primary Examiner(s): Getzow; Scott M
• Application Number:
  US11/731,203
• Time in Patent Office: 1,334 Days
• Field of Search: 607 3- 28
• US Class Current: 607/3
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3624 occurring in the atrium, i.e. atrial tachycardia
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Systems and methods to inhibit the conduction of certain spurious electrical impulses in the heart. Inhibition of spurious electrical impulses in the heart is accomplished by cooling one or more targeted portions of the heart. Optionally, inhibition of spurious electrical impulses may be accomplished by cooling of cardiac tissue in combination with pacing of the heart.

Claims

1. An apparatus for inhibiting the conduction of spurious electrical impulses in cardiac tissue comprising:

a cardiac sensor for detecting a symptom associated with an arrhythmia;

a temperature sensor, wherein the temperature sensor detects a start temperature of the cardiac tissue at the time the symptom is detected;

a processor comprising logic adapted for;

evaluating the sensed arrhythmia and the cardiac tissue start temperature; and

using the evaluation of the sensed arrhythmia and the cardiac tissue temperature, selecting one or more remedial measures from the group consisting of applying a temperature decrease to the cardiac tissue and applying a pacing pulse to the cardiac tissue;

a heat-transfer operator situated at a targeted portion, wherein the heat transfer operator is adapted to respond to the processor to remove heat from the targeted portion served by that heat-transfer operator if the temperature decrease remedial measure is selected;

a cardiac stimulation generator; and

a cardiac stimulation electrode, wherein the electrode is connected to the cardiac stimulation generator, and wherein the cardiac stimulation generator is adapted to apply a pacing pulse to the cardiac tissue if the pacing pulse remedial measure is selected.

2. The apparatus of claim 1, wherein the heat-transfer operator is selected from the group consisting of a means for applying a cooling fluid to the cardiac tissue, an electrical cooling apparatus, a mechanical cooling apparatus, and an endothermic chemical reaction.

3. The apparatus of claim 1, wherein the heat-transfer operator is a Peltier cooler.

4. The apparatus of claim 3, wherein the heat-transfer operator comprises a heat sink thermally coupled to a Peltier cooler enclosed in a housing that is implanted in the patient'"'"'s torso.

5. The apparatus of claim 4, wherein the heat sink is coupled to the Peltier cooler through mechanical contact.

6. The apparatus of claim 4, wherein the heat sink is coupled to the Peltier cooler through a thermal transfer fluid.

7. The apparatus of claim 4, wherein the Peltier cooler is electrically connected to a power source located within the housing.

8. The apparatus of claim 1, wherein the cardiac stimulation electrode is planted in the cardiac tissue.

9. The apparatus of claim 1, wherein the cardiac stimulation electrode is placed in contact with a cardiac blood pool and the pacing pulse is applied to the cardiac tissue through the cardiac blood pool.

10. The apparatus of claim 1, wherein the pacing pulse is a cathodal electrical waveform.

11. The apparatus of claim 1, wherein the pacing pulse is a biphasic electrical waveform.

12. The apparatus of claim 1, wherein the temperature sensor further measures a current temperature of the cardiac tissue and wherein the processor further comprises logic for:

monitoring the current temperature of the cardiac tissue as determined by the temperature sensor; and

ceasing the temperature decrease remedial when the current temperature is less than or equal to a desired temperature.