Analysis of eating habits

• US 7,840,269 B2
• Filed: 08/31/2007
• Issued: 11/23/2010
• Est. Priority Date: 04/18/2001
• Status: Expired due to Fees

• Current Assignee: Tylerton International Inc.
• Original Assignee: MetaCure Limited (MetaCure (USA), Inc.)
• Inventors: Policker, Shai, Aviv, Ricardo, Biton, Ophir
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US11/848,555
• Publication Number:
  US 20070299320A1
• Time in Patent Office: 1,180 Days
• Field of Search: 607/2, 607 40- 41, 607/45, 607/58, 607/62, 600/300, 600/546, 600/547, 600/585, 600/593, 128/898, 128/903, 128/920, 128/924, 128/925
• US Class Current: 607/40
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/392 Detecting gastrointestinal contractions
• CPC Class Codes: A61B 5/4023 Evaluating sense of balance
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61B 5/4233 oesophagus
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: Y10S 128/903 Radio telemetry
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.

Claims

1. A gastric apparatus, comprising:

a set of one or more implantable antral electrodes, configured to be coupled to an antral site of an antrum of a subject and to generate an antral electrode signal responsive to a property of the antrum; and

a control unit, configured to;

receive and analyze the antral electrode signal,

determine a time delay between an onset of eating by the subject and a change in electrical activity in the antrum, the change in electrical activity determined responsive to the antral electrode signal, and

responsively to the delay, determine whether food ingested by the subject is predominantly solid or liquid.

2. An apparatus according to claim 1, wherein the control unit is adapted to determine, responsive to the time delay, an extent to which the ingested food includes solid food matter.

3. An apparatus according to claim 1, further comprising a set of one or more implantable fundic electrodes, configured to be coupled to a fundic site of a fundus of a stomach of the subject, and wherein the control unit is configured to identify the onset of eating using the set of fundic electrodes.

4. An apparatus according to claim 3, wherein the control unit is configured to identify, as indicative of the onset of eating, an increase in an amplitude of an electrical potential change generated responsive to a contraction of a muscle of the fundus, detected using the set of fundic electrodes.

5. An apparatus according to claim 1, wherein the change in the electrical activity in the antrum is an onset of a decreased rate of electrical events in the antrum, and wherein the control unit is configured to determine the time delay between the onset of eating and the onset of the decreased rate of the electrical events in the antrum.

6. An apparatus according to claim 5, wherein the control unit is configured to determine, responsive to the time delay, an extent to which the ingested food includes solid food matter.

7. An apparatus according to claim 5, wherein the control unit is configured to determine, responsive to the time delay, an extent to which the ingested food includes liquid food matter.

8. An apparatus according to claim 1, wherein the change in the electrical activity in the antrum is an onset of increased electrical activity in the antrum, and wherein the control unit is configured to determine the time delay between the onset of eating and the onset of the increased electrical activity in the antrum.

9. An apparatus according to claim 8, wherein the control unit is configured to determine, responsive to the time delay, an extent to which the ingested food includes solid food matter.

10. An apparatus according to claim 8, wherein the control unit is configured to determine, responsive to the time delay, an extent to which the ingested food includes liquid food matter.

11. An apparatus according to claim 1, and comprising a set of one or more current-application electrodes, configured to be coupled to a tissue of the subject, and wherein the control unit is configured to drive an Excitable-Tissue Control (ETC) signal to the tissue, responsive to the analysis, through the set of current-application electrodes into the tissue.

12. An apparatus according to claim 1, further comprising a set of one or more current-application electrodes, configured to be coupled to a tissue of the subject, wherein the control unit is configured to drive a current through the set of current-application electrodes into the tissue.

13. An apparatus according to claim 12, wherein the set of current-application electrodes is configured to be applied to a stomach of the subject.

14. An apparatus according to claim 13, wherein the control unit is configured to configure the current to induce a sensation selected from the group consisting of:

a sensation of discomfort, and a sensation of nausea.

15. An apparatus according to claim 12, wherein the set of current-application electrodes is configured to be applied to an esophageal site of the subject.

16. An apparatus according to claim 1, further comprising a signal generator, wherein the control unit is configured to actuate the signal generator to convey an ingestion-control signal to the subject.

17. An apparatus according to claim 1, wherein the apparatus is configured to treat obesity of the subject.

18. An apparatus according to claim 1, wherein the change in the electrical activity in the antrum is an onset of the electrical activity, and wherein the control unit is configured to determine the time delay between the onset of eating and the onset of the electrical activity.

19. An apparatus according to claim 1, further comprising at least one sensor, configured to placed at a site selected from the group consisting of:

a site on an esophagus and a site on a throat, and to generate a signal indicative of swallowing, and wherein the control unit is configured to identify the onset of eating responsively to the signal.

20. A gastric apparatus, comprising:

a gastric sensor, configured to be coupled to a gastric site of a subject and to generate a gastric sensor signal responsive to a property of the gastric site and

a control unit, configured to receive and analyze the gastric sensor signal, and to determine, responsive thereto, a characteristic of a food ingested by the subject, the characteristic selected from the group consisting of;

whether the food is predominantly solid or liquid, and a caloric content of the food,

wherein the gastric sensor comprises a set of one or more fundic electrodes, configured to generate a fundic electrode signal responsive to a property of the fundus, and wherein the control unit is configured to receive and analyze the fundic electrode signal, and to determine, responsive thereto, the characteristic of the ingested food, and

wherein the fundic electrode set is configured to generate the fundic electrode signal responsive to an electrical potential change generated responsive to a contraction of a muscle of the fundus.

21. An apparatus according to claim 20, wherein the control unit is configured to determine, responsive to a parameter of the fundic electrode signal, the characteristic of the ingested food, the parameter selected from the group consisting of:

an amplitude of the fundic electrode signal, a duration of the fundic electrode signal, and a change in rate of fundic electrode signal events.

22. An apparatus according to claim 20, wherein the control unit is configured to determine, responsive to a frequency of the fundic electrode signal, the characteristic of the ingested food.

23. An apparatus according to claim 20, wherein the control unit is configured to identify an increase in an amplitude of the fundic electrode signal as indicative of an event selected from the group consisting of:

eating and an onset of eating.

24. An apparatus according to claim 20, wherein the control unit is configured to identify an increase in a frequency of the fundic electrode signal as indicative of an event selected from the group consisting of:

eating and an onset of eating.

25. An apparatus according to claim 24, wherein the control unit is configured to detect the onset of the selected event, responsive to the increase in the frequency being greater than about 10 percent.

26. An apparatus according to claim 20, wherein the control unit is configured to identify a substantial return towards a baseline value of a parameter of the fundic electrode signal as indicative of a termination of eating, the parameter selected from the group consisting of:

an amplitude of the fundic electrode signal, and a frequency of the fundic electrode signal.

27. A method comprising:

coupling a gastric sensor to a gastric site of the subject, and sensing a property of the gastric site using the gastric sensor;

analyzing the property of the gastric site; and

determining, responsive to the analysis, a characteristic of a food ingested by the subject, the characteristic selected from the group consisting of;

whether the food is predominantly solid or liquid, and a caloric content of the food,

wherein the gastric site includes an antral site, and wherein sensing the property comprises sensing a property of an antrum of a stomach.

28. A method according to claim 27, wherein sensing the property of the antrum comprises sensing an electrical property of the antrum.

29. A method according to claim 28, wherein determining the characteristic of the food comprises:

determining a time delay between an onset of eating by the subject and a change in electrical activity in the antrum; and

responsively to the delay, determining whether food ingested by the subject is predominantly solid or liquid.

30. A method according to claim 29, wherein determining whether the ingested food is solid or liquid comprises determining, responsive to the time delay, an extent to which the ingested food includes solid food matter.

31. A method according to claim 29, wherein the change in the electrical activity in the antrum is an onset of a decreased rate of electrical events in the antrum, and wherein determining the time delay comprises determining the time delay between the onset of eating and the onset of the decreased rate of the electrical events in the antrum.

32. A method according to claim 29, wherein the change in the electrical activity in the antrum is an onset of increased electrical activity in the antrum, and wherein determining the time delay comprises determining the time delay between the onset of eating and the onset of the increased electrical activity in the antrum.

33. A method according to claim 29, wherein determining the time delay comprises coupling a set of one or more implantable fundic electrodes to a fundic site of a fundus of a stomach of the subject, and identifying the onset of eating using the fundic electrodes.

34. A method according to claim 33, wherein identifying comprises identifying an increase in an amplitude of an electrical potential change generated responsive to a contraction of a muscle of the fundus, detected using the fundic electrodes.

35. A method according to claim 29, wherein determining the time delay comprises placing at least one sensor at a site selected from the group consisting of:

a site on an esophagus and a site on a throat, using the sensor to generate a signal indicative of swallowing, and identifying the onset of eating responsively to the signal.

36. A method according to claim 27, and comprising driving a current into tissue of the subject responsive to the analysis.

37. A method according to claim 36, wherein driving the current comprises driving the current into a stomach of the subject.

38. A method according to claim 37, wherein driving the current comprises configuring the current to induce a sensation selected from the group consisting of:

a sensation of discomfort, and a sensation of nausea.

39. A method according to claim 36, wherein driving the current comprises applying an Excitable-Tissue Control (ETC) signal to the tissue.

40. An apparatus according to claim 36, wherein driving the current comprises driving the current into an esophageal site of the subject.

41. A method according to claim 27, further comprising conveying an ingestion-control signal to the subject responsive to the analysis.

42. A method according to claim 37, further comprising treating obesity of the subject responsive to the analysis.

43. A method comprising:

coupling a gastric sensor to a gastric site of the subject, and sensing a property of the gastric site using the gastric sensor;

analyzing the property of the gastric site and

determining, responsive to the analysis, a characteristic of a food ingested by the subject, the characteristic selected from the group consisting of;

whether the food is predominantly solid or liquid, and a caloric content of the food,

wherein the gastric site includes a fundic site, and wherein sensing the property comprises sensing a property of a fundus of a stomach.

44. A method according to claim 43, wherein sensing the property of the fundus comprises sensing an electrical property of the fundus.

45. A method according to claim 44, wherein the fundic site includes two fundic sites, and wherein sensing the electrical property comprises sensing a measure of electrical impedance between the two fundic sites.

46. A method according to claim 44, wherein sensing the property comprises sensing an electrical potential change generated responsive to a contraction of a muscle of the fundus.

47. A gastric apparatus, comprising:

a gastric sensor, configured to be coupled to a gastric site of a subject and to generate a gastric sensor signal responsive to a property of the gastric site; and

a control unit, configured to receive and analyze the gastric sensor signal, and to determine, responsive thereto, a caloric content of the food.

48. An apparatus according to claim 47, wherein the gastric sensor comprises a set of one or more implantable antral electrodes, configured to be coupled to an antral site of an antrum of a stomach of the subject and to generate an antral electrode signal responsive to a property of the antrum, and wherein the control unit is configured to receive and analyze the antral electrode signal, and to determine, responsive thereto, the caloric content of the ingested food.

49. A gastric apparatus, comprising:

a gastric sensor, configured to be coupled to a gastric site of a subject and to generate a gastric sensor signal responsive to a property of the gastric site

a set of one or more current-application electrodes, configured to be coupled to a tissue of a stomach of the subject; and

a control unit, configured to;

receive and analyze the gastric sensor signal,

determine, responsive thereto, a characteristic of a food ingested by the subject, the characteristic selected from the group consisting of;

whether the food is predominantly solid or liquid, and a caloric content of the food,

responsive to the analysis, drive a current through the set of current-application electrodes into the tissue, and

configure the current to induce a feeling of satiation by performing an action selected from the group consisting of;

configuring the current to induce contraction of stomach muscles, and configuring the current to enhance mobility of chyme in the stomach.

50. An apparatus according to claim 49, wherein the gastric sensor comprises a set of one or more fundic sensors, configured to be coupled to a fundic site of a fundus of a stomach of the subject and to generate a fundic sensor signal responsive to a property of the fundus, and wherein the control unit is configured to receive and analyze the fundic sensor signal, and to determine, responsive thereto, the characteristic of the ingested food.

51. An apparatus according to claim 50, wherein the fundic sensor set comprises a set of one or more fundic electrodes, and wherein the control unit is configured to determine, the characteristic of the ingested food using the fundic electrodes.

52. An apparatus according to claim 51, wherein the fundic electrode set comprises two fundic electrodes, configured to be coupled to two sites of the fundus, and wherein the control unit is configured to identify a measure of electrical impedance between the two sites of the fundus.

53. An apparatus according to claim 52, wherein the control unit is configured to determine the characteristic of the ingested food, responsive to a change in the measure of electrical impedance.

54. An apparatus according to claim 49, wherein the gastric sensor comprises a set of one or more implantable antral sensors, configured to be coupled to an antral site of an antrum of a stomach of the subject and to generate an antral sensor signal responsive to a property of the antrum, and wherein the control unit is configured to receive and analyze the antral sensor signal, and to determine, responsive thereto, the characteristic of the ingested food.

55. An apparatus according to claim 54, wherein the antral sensor set comprises a set of implantable antral electrodes, configured to generate an antral electrode signal responsive to a property of the antrum, and wherein the control unit is configured to receive and analyze the antral electrode signal, and to determine, responsive thereto, the characteristic of the ingested food.

56. An apparatus according to claim 55, wherein the control unit is configured to determine, responsive to a parameter of the antral electrode signal, the characteristic of the ingested food, the parameter selected from the group consisting of:

an amplitude of the antral electrode signal, a duration of the antral electrode signal, and a change in a rate of antral electrode signal events.

57. An apparatus according to claim 55, wherein the control unit is configured to determine, responsive to a frequency of the antral electrode signal, the characteristic of the ingested food.

58. An apparatus according to claim 55, wherein the control unit is configured to determine, responsive to a spike energy per antral cycle of electrical activity, the characteristic of the ingested food.

59. An apparatus according to claim 49, wherein the control unit is configured to configure the current to induce the contraction of the stomach muscles in order to induce the feeling of satiation.

60. An apparatus according to claim 59, wherein the control unit is configured to configure the current to induce a generally steady-state contraction of a corpus of the stomach.

61. An apparatus according to claim 49, wherein the control unit is configured to configure the current to enhance the mobility of the chyme in the stomach in order to induce the feeling of satiation.

62. A method comprising:

coupling a gastric sensor to a gastric site of the subject, and sensing a property of the gastric site using the gastric sensor;

analyzing the property of the gastric site and

determining, responsive to the analysis, a caloric content of the food.

63. A method according to claim 62, wherein the gastric site includes an antral site, and wherein sensing the property comprises sensing an electrical property of an antrum of a stomach.

64. A method comprising:

coupling a gastric sensor to a gastric site of the subject, and sensing a property of the gastric site using the gastric sensor;

analyzing the property of the gastric site;

determining, responsive to the analysis, a characteristic of a food ingested by the subject, the characteristic selected from the group consisting of;

whether the food is predominantly solid or liquid, and a caloric content of the food;

driving a current into tissue of a stomach of the subject responsive to the analysis; and

configuring the current to induce a feeling of satiation, by performing an action selected from the group consisting of;

configuring the current to induce contraction of stomach muscles, and configuring the current to enhance mobility of chyme in the stomach.

65. A method according to claim 64, wherein configuring the current comprises configuring the current to induce the contraction of the stomach muscles in order to induce the feeling of satiation.

66. A method according to claim 65, wherein configuring the current comprises configuring the current to induce a generally steady-state contraction of a corpus of the stomach.

67. A method according to claim 64, wherein configuring the current comprises configuring the current to enhance the mobility of the chyme in the stomach in order to induce the feeling of satiation.