Stimulus regimens for cardiovascular reflex control
First Claim
Patent Images
1. A method of inducing a baroreceptor signal to effect a change in the baroreflex system in a patient, the method comprising the steps of:
- providing a baroreceptor activation device including a first means for outputting an electrical signal to electrically induce a baroreceptor signal and a second means for outputting an electrical signal to electrically induce a baroreceptor signal, the first means for outputting an electrical signal adapted to be positioned proximate a first baroreceptor location and the second means for outputting an electrical signal adapted to be positioned proximate a second baroreceptor location; and
alternating the electrical signal between the first means for outputting and the second means for outputting to promote long term efficacy of inducing baroreceptor signals and reduce exposure of a single baroreceptor location.
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Abstract
Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption.
507 Citations
16 Claims
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1. A method of inducing a baroreceptor signal to effect a change in the baroreflex system in a patient, the method comprising the steps of:
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providing a baroreceptor activation device including a first means for outputting an electrical signal to electrically induce a baroreceptor signal and a second means for outputting an electrical signal to electrically induce a baroreceptor signal, the first means for outputting an electrical signal adapted to be positioned proximate a first baroreceptor location and the second means for outputting an electrical signal adapted to be positioned proximate a second baroreceptor location; and alternating the electrical signal between the first means for outputting and the second means for outputting to promote long term efficacy of inducing baroreceptor signals and reduce exposure of a single baroreceptor location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system for inducing a baroreceptor signal to effect a change in the baroreflex system in a patient, the system comprising:
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a baroreceptor activation device including a first means for outputting adapted to be implanted proximate a first baroreceptor location, and a second means for outputting adapted to be positioned proximate a second baroreceptor location, such that activation of the baroreceptor activation device induces a baroreceptor signal in the patient; and a control system connected to the baroreceptor activation device, the control system including a processor and a memory, wherein the memory includes software defining a stimulus regimen, the control system generating a control signal that activates one of the first means for outputting or the second means for outputting of the baroreceptor activation device as a function of the stimulus regimen, the stimulus regimen causing the control signal to be changed to promote long term efficacy of inducing baroreceptor signals and reduce exposure of a single baroreceptor location by alternating the control signal between the first means for outputting and the second means for outputting. - View Dependent Claims (11, 12, 13)
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14. A method of inducing a baroreceptor signal to effect a change in the baroreflex system in a patient, the method comprising the steps of:
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providing a baroreceptor activation device including a first means for outputting an electrical signal to electrically induce a baroreceptor signal and a second means for outputting an electrical signal to electrically induce a baroreceptor signal, providing instructions for operating the baroreflex activation device, comprising; implanting the baroreceptor activation device such that the first means for outputting an electrical signal is proximate a first baroreceptor location in the patient and the second means for outputting an electrical signal is proximate a second baroreceptor location; alternating the electrical signal between the first means for outputting and the second means for outputting to promote long term efficacy of inducing baroreceptor signals and reduce exposure of a single baroreceptor location. - View Dependent Claims (15, 16)
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Specification