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Temperature controller for small fluid samples with different heat capacities

  • US 7,841,247 B2
  • Filed: 01/20/2006
  • Issued: 11/30/2010
  • Est. Priority Date: 01/25/2005
  • Status: Expired due to Fees
First Claim
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1. A temperature controlled fluidic sample system comprising:

  • a fluidic sample device comprising;

    a first substrate block having a first inner surface and a first outer surface;

    a second substrate block having a second inner surface and a second outer surface;

    a first groove formed in the first inner surface, the first groove having first and second ends opening to a peripheral edge of the first substrate block;

    the first and second inner surfaces of the first and second substrate blocks facing each other so as to form a first through channel between the first and second substrate, wherein;

    the first through channel has first and second ends opening to a peripheral edge of the fluidic sample device;

    the first through channel incorporates said first groove;

    the first through channel is located between two imaginary planes that are spaced apart by a height (h) of the first through channel, the two imaginary planes being parallel to one another and defining between them a first volume in which the first through channel resides; and

    at least one temperature sensor configured to measure a temperature within the first volume;

    a heater thermally coupled to said first outer surface;

    a heat sink thermally coupled to said second outer surface; and

    a temperature controller configured to receive temperature information from said temperature sensor and cause the heater to provide heat and the heat sink to provide cooling, such that;

    a temperature gradient is formed between the first outer surface and the second outer surface; and

    a desired temperature is maintained within said first volume.

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