Apolipoprotein E genotyping and accompanying internet-based health management system

• US 7,842,506 B2
• Filed: 02/06/2007
• Issued: 11/30/2010
• Est. Priority Date: 05/27/2003
• Status: Expired due to Fees

• Current Assignee: Berkeley HeartLab, Inc. (Quest Diagnostics Incorporated)
• Original Assignee: Berkeley HeartLab, Inc. (Quest Diagnostics Incorporated)
• Inventors: Hall, Christopher, Shewmake, David T., Lanier, Vance Jr.
• Primary Examiner(s): WALLENHORST, MAUREEN
• Application Number:
  US11/702,961
• Publication Number:
  US 20070224619A1
• Time in Patent Office: 1,393 Days
• Field of Search: 436/63, 436/71, 436/86, 435/6, 435/11, 422/68.1, 422/99, 702/19, 702/20, 702/32, 705/2, 705/3, 600/300
• US Class Current: 436/71
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 2600/156 Polymorphic or mutational markers
• CPC Class Codes: G01N 33/92 involving lipids, e.g. cholesterol , lipoproteins, or their receptors steroid hormones G01N33/743
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16H 20/60 relating to nutrition control, e.g. diets
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient'"'"'s Apo E information; and 3) an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a diet and treatment plan for the patient.

Claims

1. A method for selecting a diet plan for a patient, comprising

(a) determining the Apo E genotype of the patient;

and

(b) selecting a diet plan based on the Apo E genotype of the patient;

wherein the diet plan comprises;

(i) a moderate-fat diet (35% fat) when the patient'"'"'s Apo E genotype is e2/2 or e2/3;

(ii) a preventative (25% fat) diet when the patient'"'"'s Apo E genotype is e3/3 or e2/4;

or

(iii) a low-fat (20% fat) diet when the patient'"'"'s Apo E genotype is e4/4 or e3/4.

2. A method for preventing cardiovascular disease in a patient with an increased risk of developing cardiovascular disease comprising:

(a) determining the Apo E genotype of the patient;

(b) prescribing a low-fat diet (20% fat) to the patient when the Apo E genotype of the patient determined from (a) is e4/4 or e3/4.

3. A method for preventing cardiovascular disease in a patient with an increased risk of developing cardiovascular disease comprising:

(a) determining the Apo E genotype of the patient;

(b) identifying the patient as having an increased risk of developing cardiovascular disease when the Apo E genotype of the patient determined from (a) is e4/4 or e3/4;

(c) prescribing a low-fat diet (20% fat) to the patient.

4. A method for preventing cardiovascular disease in a patient with an increased risk of developing cardiovascular disease comprising:

(a) determining the Apo E genotype of the patient;

(b) identifying the patient as having an increased risk of developing cardiovascular disease when the Apo E genotype of the patient determined from (a) is e4/4 or e3/4;

(c) selecting a low-fat diet (20% fat) for the patient identified in (b); and

(d) prescribing the diet selected in step (c) to the patient.