High frequency obesity treatment

• US 7,844,338 B2
• Filed: 06/30/2004
• Issued: 11/30/2010
• Est. Priority Date: 02/03/2003
• Status: Expired due to Fees

• Current Assignee: ReShape LifeSciences, Inc.
• Original Assignee: EnteroMedics, Inc. (ReShape LifeSciences, Inc.)
• Inventors: Knudson, Mark B., Wilson, Richard R., Tweden, Katherine S., Conrad, Timothy R.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): SARCIONE, JESSICA LYNN
• Application Number:
  US10/881,045
• Publication Number:
  US 20050038484A1
• Time in Patent Office: 2,344 Days
• Field of Search: 607 40- 41, 607/2, 607 45- 46, 607/133, 607/149, 607/48
• US Class Current: 607/40
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/321 Electromedical belts
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36085 Eating disorders or obesity
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters

Abstract

A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.

Claims

1. A method for treating obesity comprising:

positioning an electrode on a vagus nerve of an obese patient at a location below a vagal innervation of the heart, with the vagus nerve innervating at least one alimentary tract organ;

treating the patient'"'"'s obesity by applying an electrical treatment signal to the electrode with the electrical treatment signal having;

a) a frequency selected for said signal to at least partially downregulate nerve impulses on said vagus nerve, wherein said signal has a frequency in excess of 200 Hz;

b) a plurality of on-times separated by a plurality of off-times, said signal applied during said on-times and not applied during said off-times, wherein a duration of the off-times is selected to allow at least partial recovery of the activity of said vagus nerve, and wherein the on and off times of the electrical signal treatment reduce pancreatic and biliary output via inhibition of pancreo-biliary output of the obese patient; and

wherein the electrical signal treatment is applied without simultaneously applying a neural impulse-inducing secondary electrical signal to the vagus nerve on a proximal side of said location.

2. A method according to claim 1 wherein application of said electrical signal is variable by a controller to alter a characteristic of said electrical treatment signal.

3. A method according to claim 2 wherein said electrical treatment signal is regulated to heighten a sensation of satiety of said patient.

4. A method according to claim 1 wherein a duration of said off time is selected to avoid excessive fecal fat in a stool of said patient.

5. A method according to claim 1 wherein said frequency is selected to block afferent signals on the vagus nerve.

6. A method according to claim 1 wherein said frequency is selected to block efferent signals on the vagus nerve.

7. A method according to claim 1 wherein said frequency is selected to block both afferent and efferent signals on the vagus nerve.

8. A method according to claim 1 wherein said frequency is selected to block myelinated fibers of the vagus nerve.

9. A method according to claim 1 wherein said frequency is selected to block unmyelinated fibers of the vagus nerve.

10. A method according to claim 1 wherein said frequency is selected to block both myelinated and unmyelinated fibers of the vagus nerve.

11. A method according to claim 1 wherein the electrical treatment signal is applied to a vagal trunk.

12. A method according to claim 1 wherein the electrical treatment signal is applied to a vagal branch.

13. A method according to claim 1 wherein the electrical treatment signal is applied to both an anterior vagus nerve and a posterior vagus nerve of the patient.

14. A method according to claim 1 wherein the electrical treatment signal is applied to a selected one of an anterior vagus nerve and a posterior vagus nerve of the patient.

15. A method according to claim 1 wherein the electrical treatment signal is applied to the vagus nerve at a location near or distal to a diaphragm of the patient.

16. A method according to claim 1 further comprising monitoring a vagal activity of said patient.

17. A method according to claim 16, wherein said monitoring includes monitoring a discomfort of said patient.

18. A method according to claim 16, wherein said monitoring includes monitoring a fecal fat content of said patient.

19. A method according to claim 16, wherein said monitoring includes electrically monitoring a neural activity of said patient.

20. A method according to claim 1 wherein said frequency is at least 500 Hz.

21. A method according to claim 1, wherein said on time and said off time is varied to obtain an average vagal activity of at least 30%.

22. A method according to claim 1, wherein said on time is about two to five minutes.

23. A method according to claim 1, wherein said off time is selected to increase weight loss.

24. A method according to claim 1, wherein said off time is selected to increase patient comfort.