Coated implantable medical device

• US 7,846,202 B2
• Filed: 12/27/2007
• Issued: 12/07/2010
• Est. Priority Date: 06/07/1995
• Status: Expired due to Fees

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated), MED Institute, Inc. (Cook Group Incorporated)
• Inventors: Bates, Brian L., Fearnot, Neal E., Kozma, Thomas G., Ragheb, Anthony O., Voorhees, William D. III
• Primary Examiner(s): PREBILIC, PAUL B
• Application Number:
  US11/965,385
• Publication Number:
  US 20080183268A1
• Time in Patent Office: 1,076 Days
• Field of Search: 623/1.15, 623 142- 143, 623/23.7, 623/2.14, 623/2.18
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/885 comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir

Abstract

A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

Claims

1. An implantable medical device comprising:

an expandable metal vascular stent having at least one metal surface, the stent being composed of a base material;

at least one coating layer comprising parylene or a parylene derivative that is positioned directly against the at least one metal surface;

at least one layer comprising a first bioactive material;

wherein the at least one layer comprising the first bioactive material is positioned on the coating layer; and

at least one layer of a porous layer comprising a first polymer positioned on the at least one layer comprising the first bioactive material;

wherein upon implantation into a patient, the porous layer controls release of the bioactive agent from the at least one layer comprising the first bioactive material.

2. The medical device of claim 1, where the first polymer is a biostable polymer with a relatively low chronic tissue response selected from the group consisting of polyurethanes, silicones, and polyesters.

3. The medical device of claim 1, where the first polymer is a polyurethane.

4. The medical device of claim 1, where the base material is a biocompatible metal selected from the group consisting of stainless steel, nickel, silver, platinum, gold, titanium, tantalum, iridium, tungsten, nitinol, and inconel.

5. The medical device of claim 3, where the base material is a biocompatible metal selected from the group consisting of stainless steel, nickel, silver, platinum, gold, titanium, tantalum, iridium, tungsten, nitinol, and inconel.

6. The medical device of claim 5, where the base material is nitinol.

7. The medical device of claim 6, wherein the bioactive material is paclitaxel or a derivative thereof.

8. The medical device of claim 1, wherein the bioactive material is paclitaxel or a derivative thereof.

9. The medical device of claim 1, wherein the bioactive material is paclitaxel.