Method and device for ultrasonically manipulating particles within a fluid
First Claim
1. A fluid-handling device for ultrasonic manipulation of fluid-borne particles, comprising, in combination:
- a fluid-handling manifold having a fluid inlet port and defining a fluid-handling void comprising at least a first fluid channel;
a second fluid channel in fluid communication with the first fluid channel at an intersection within the ultrasonic cavity; and
an ultrasonic particle manipulator defining an ultrasonic cavity and comprising at least one ultrasonic transducer, the first fluid channel extending from the inlet port to the ultrasonic cavity and the ultrasonic particle manipulator being operative to establish an ultrasonic standing wave field in particle-bearing fluid in the first fluid channel at the ultrasonic cavity,wherein the ultrasonic cavity has a non-uniform configuration;
wherein the first fluid channel and the second fluid channel extend substantially parallel each other on opposite sides of a dividing wall between them, andwherein the intersection comprises a passageway through the dividing wall.
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Accused Products
Abstract
Fluid-handling methods and devices for ultrasonic manipulation of fluid-borne particles comprise a fluid-handling manifold and an ultrasonic particle manipulator defining an ultrasonic cavity within the manifold. Fluid-borne particles introduced into the manifold are manipulated by controlling ultrasonic standing waves at the ultrasonic cavity. Cavities having non-uniform configurations, asymmetric standing waves and/or multiple ultrasonic cavities within the manifold are operative to control the movement of the fluid-borne particles, optionally including collecting and holding such particles, transferring particles through an intersection from one channel to another, etc. Solid phase extraction (SPE) particles, biological particles and other fluid-borne particles can be manipulated within the fluid-handling manifold.
143 Citations
29 Claims
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1. A fluid-handling device for ultrasonic manipulation of fluid-borne particles, comprising, in combination:
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a fluid-handling manifold having a fluid inlet port and defining a fluid-handling void comprising at least a first fluid channel; a second fluid channel in fluid communication with the first fluid channel at an intersection within the ultrasonic cavity; and an ultrasonic particle manipulator defining an ultrasonic cavity and comprising at least one ultrasonic transducer, the first fluid channel extending from the inlet port to the ultrasonic cavity and the ultrasonic particle manipulator being operative to establish an ultrasonic standing wave field in particle-bearing fluid in the first fluid channel at the ultrasonic cavity, wherein the ultrasonic cavity has a non-uniform configuration; wherein the first fluid channel and the second fluid channel extend substantially parallel each other on opposite sides of a dividing wall between them, and wherein the intersection comprises a passageway through the dividing wall. - View Dependent Claims (2, 3, 4)
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5. A fluid-handling device for ultrasonic manipulation of fluid-borne particles, comprising, in combination:
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a fluid-handling manifold having a fluid inlet port and defining a fluid-handling void comprising at least a first fluid channel; and an ultrasonic particle manipulator defining an ultrasonic cavity and comprising at least one ultrasonic transducer, the first fluid channel extending from the inlet port to the ultrasonic cavity and the ultrasonic particle manipulator being operative to establish an ultrasonic standing wave field in particle-bearing fluid in the first fluid channel at the ultrasonic cavity, wherein the fluid-handling void further comprises a second fluid channel in fluid communication with the first fluid channel at an intersection within the ultrasonic cavity; the ultrasonic particle manipulator is operative to establish an ultrasonic standing wave field having an axial direction of standing wave propagation substantially perpendicular to the direction of fluid communication through the intersection; the cross-sectional configuration of the ultrasonic cavity is non-uniform in the direction of fluid communication through the intersection; and the ultrasonic particle manipulator is operative to collect fluid-borne particles from fluid in the first fluid channel and move collected fluid-borne particles through the intersection to the second fluid channel by varying the actuation frequency of the ultrasonic transducer. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A fluid-handling device for ultrasonic manipulation of fluid-borne particles, comprising, in combination:
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a fluid-handling manifold having a fluid inlet port; a first fluid channel in fluid communication with the fluid inlet port; an ultrasonic particle manipulator comprising at least one ultrasonic transducer and an acoustic reflector positioned opposite the ultrasonic transducer, the ultrasonic transducer and the acoustic reflector cooperatively defining between them an ultrasonic cavity and operative to separate fluid-borne particles from fluid flowed through the ultrasonic cavity by establishing an ultrasonic standing wave field in a portion of the first fluid channel extending through the ultrasonic cavity; and a second fluid channel in fluid communication with the first fluid channel at an intersection within the ultrasonic cavity, wherein the first fluid channel and the second fluid channel extend substantially parallel each other on opposite sides of a dividing wall between them, and wherein the intersection comprises a passageway through the dividing wall. - View Dependent Claims (20, 21, 22, 23)
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24. A fluid-handling device for ultrasonic manipulation of fluid-borne particles, comprising:
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an ultrasonic particle manipulator defining an ultrasonic cavity and comprising at least one ultrasonic transducer and an acoustic reflector; a first fluid channel extending into the ultrasonic cavity; and a second fluid channel in fluid communication with the first fluid channel at an intersection within the ultrasonic cavity, wherein the first fluid channel and the second fluid channel extend substantially parallel each other on opposite sides of a dividing wall between them, and the intersection comprises a passageway through the dividing wall, wherein the ultrasonic particle manipulator is operative to establish an ultrasonic standing wave field in fluid in the ultrasonic cavity, and wherein the spacing between the ultrasonic transducer and the acoustic reflector is not more than 300 microns. - View Dependent Claims (25, 26, 27, 28, 29)
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Specification