PCSK9 polypeptides
First Claim
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1. An isolated polypeptide comprising a sequence selected from the group consisting of:
- (a) an isolated polypeptide comprising amino acids 1 to 315 of SEQ ID NO;
2;
(b) an isolated polypeptide comprising amino acids 2 to 315 of SEQ ID NO;
2;
(c) an isolated polypeptide encoded by nucleotides 250 to 1194 of SEQ ID NO;
1; and
(d) an isolated polypeptide encoded by nucleotides 253 to 1194 of SEQ ID NO;
1.
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Abstract
The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
33 Citations
14 Claims
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1. An isolated polypeptide comprising a sequence selected from the group consisting of:
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(a) an isolated polypeptide comprising amino acids 1 to 315 of SEQ ID NO;
2;(b) an isolated polypeptide comprising amino acids 2 to 315 of SEQ ID NO;
2;(c) an isolated polypeptide encoded by nucleotides 250 to 1194 of SEQ ID NO;
1; and(d) an isolated polypeptide encoded by nucleotides 253 to 1194 of SEQ ID NO;
1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An isolated polypeptide comprising the polypeptide encoded by the plasmid PCSK-9-b in ATCC Deposit No. PTA-7622.
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10. An isolated polypeptide consisting of amino acids 10 to 256 of SEQ ID NO:
- 2, wherein the polypeptide is capable of lowering the level of LDL uptake in the mammalian cells in which the polypeptide is recombinantly expressed.
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11. An isolated polypeptide comprising amino acids 1 to 279 of SEQ ID NO:
- 2, wherein the polypeptide is capable of lowering the level of LDL uptake in mammalian cells in which the polypeptide is recombinantly expressed.
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12. An isolated polypeptide comprising amino acids 37 to 315 of SEQ ID NO:
- 2, wherein the polypeptide is capable of lowering the level of LDL uptake in mammalian cells in which the polypeptide is recombinantly expressed.
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13. An isolated polypeptide comprising amino acids 2 to 284 of SEQ ID NO:
- 2, wherein the polypeptide is capable of lowering the level of LDL uptake in mammalian cells in which the polypeptide is recombinantly expressed.
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14. An isolated polypeptide comprising amino acids 16 to 315 of SEQ ID NO:
- 2, wherein the polypeptide is capable of lowering the level of LDL uptake in mammalian cells in which the polypeptide is recombinantly expressed.
Specification