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Oligomeric compounds for the modulation of HIF-1alpha expression

  • US 7,846,911 B2
  • Filed: 10/15/2009
  • Issued: 12/07/2010
  • Est. Priority Date: 04/05/2002
  • Status: Expired due to Fees
First Claim
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1. A method of treating a mammal suffering from cancer, comprising administering to the mammal a therapeutically effective amount of an oligonucleotide compound targeted to Hif-1alpha and having the base sequence set forth in SEQ ID NO:

  • 55, wherein the cancer is selected from the group consisting of kidney cancer, melanoma, glioblastoma and prostate cancer, and wherein the oligonucleotide compound comprises one or more LNA units.

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