Compounds modulating c-kit and c-fms activity and uses therefor

• US 7,846,941 B2
• Filed: 05/16/2006
• Issued: 12/07/2010
• Est. Priority Date: 05/17/2005
• Status: Active Grant

• Current Assignee: Plexxikon Inc (Daiichi Sankyo Company Limited)
• Original Assignee: Plexxikon Inc (Daiichi Sankyo Company Limited)
• Inventors: Wu, Guoxian, Artis, Dean R., Zhu, Hongyao, Spevak, Wayne, Zhang, Jiazhong, Zhang, Chao, Ibrahim, Prabha N., Bremer, Ryan, Hurt, Clarence R., Zuckerman, Rebecca
• Primary Examiner(s): AULAKH, CHARANJIT
• Application Number:
  US11/435,381
• Publication Number:
  US 20070032519A1
• Time in Patent Office: 1,666 Days
• Field of Search: 514/300, 514/234.5, 546/113, 544/127
• US Class Current: 514/300
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 3/14 for calcium homeostasis vitamin D A61P3/02; parathyroid hormones A61P5/18; calcitonin A61P5/22; osteoporosis A61P19/10; bone metastasis A61P35/04
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 35/04 specific for metastasis
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 471/04 : Ortho-condensed systems

Abstract

Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.

Claims

1. A compound having the chemical structure

2. The compound according to claim 1, wherein Y₁ is CH and Y₂ is CR⁵.

3. The compound according to claim 2, wherein R⁵ is fluoro, chloro, lower alkyl or lower alkoxy.

4. The compound according to claim 2, wherein R⁵ is chloro or methoxy.

5. The compound according to claim 1, wherein Y₂ is CH and Y₁ is CR⁴.

6. The compound according to claim 5, wherein R⁴ is fluoro, chloro, lower alkyl or lower alkoxy.

7. The compound according to claim 5, wherein R⁴ is chloro or methoxy.

8. A composition comprising:

a pharmaceutically acceptable carrier; and

a compound according to claim 1.

9. A kit comprising a composition according to claim 8.