Amphiphilic block copolymers and their use
First Claim
1. A coating composition for adhering an implant to a biological tissue comprising an amphiphilic block copolymer having at least one block of hydrophilic units and at least one block of hydrophobic units wherein said at least one hydrophobic block contains siloxane units, the siloxane units having the formula:
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Abstract
The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.
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Citations
20 Claims
- 1. A coating composition for adhering an implant to a biological tissue comprising an amphiphilic block copolymer having at least one block of hydrophilic units and at least one block of hydrophobic units wherein said at least one hydrophobic block contains siloxane units, the siloxane units having the formula:
- 2. A coating composition for adhering an implant to a biological tissue comprising an amphiphilic block copolymer having at least one block of hydrophilic units and at least one block of hydrophobic units wherein said at least one hydrophobic block contains siloxane units, the siloxane units having the formula:
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10. A coating composition for adhering an implant to a biological tissue comprising an amphiphilic block copolymer comprising an amphiphilic block copolymer comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein said at least one hydrophobic block contains siloxane units, and wherein said amphiphilic block copolymer is an isothiocyanate terminated poly(ethylene glycol)-b-polysiloxane having the formula:
Specification