×

Pharmacokinetic modulation and compositions for modified FN3 polypeptides

  • US 7,847,062 B2
  • Filed: 07/07/2006
  • Issued: 12/07/2010
  • Est. Priority Date: 12/05/2003
  • Status: Active Grant
First Claim
Patent Images

1. A polypeptide comprising a fibronectin type III tenth (10Fn3) domain of 80 to 150 amino acids, wherein the 10Fn3 domain binds to a target molecule with a KD of less than 100 nM and comprises an amino acid sequence at least 60% identical to SEQ ID NO:

  • 5;

    wherein the 10Fn3 domain further comprises a C-terminal tail having the sequence of EIDKPCQ (residues 97-103 of SEQ ID NO;

         199), and wherein the cysteine residue of the C-terminal tail is conjugated to a moiety selected from the group consisting of;

    a polyoxyalkylene moiety, a radioactive moiety, a chemotherapeutic agent, and a label.

View all claims
  • 5 Assignments
Timeline View
Assignment View
    ×
    ×