Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
First Claim
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1. A transdermal delivery device to passively deliver active agents to a biological interface, comprising:
- an active agent reservoir comprising a first active agent of a first polarity;
an outer active agent membrane comprising a second active agent of the first polarity distributed therein, the outer active agent membrane taking the form of an ion-exchange membrane of a second polarity; and
an interfacial layer having a first side adjacent to the outer active agent membrane and a second side configured to contact a biological interface, the interfacial layer comprising a plurality of freely diffusible monovalent co-ions of the first polarity.
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Abstract
A transdermal delivery device to passively deliver active agents to a biological interface includes an active agent reservoir comprising a first active agent of a first polarity; an outer active agent membrane taking the form of an ion-exchange membrane of a second polarity, an interfacial layer having a plurality of freely diffusible monovalent co-ions of the first polarity and having a first side adjacent to the outer active agent membrane and a second side configured to contact a biological interface.
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Citations
9 Claims
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1. A transdermal delivery device to passively deliver active agents to a biological interface, comprising:
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an active agent reservoir comprising a first active agent of a first polarity; an outer active agent membrane comprising a second active agent of the first polarity distributed therein, the outer active agent membrane taking the form of an ion-exchange membrane of a second polarity; and an interfacial layer having a first side adjacent to the outer active agent membrane and a second side configured to contact a biological interface, the interfacial layer comprising a plurality of freely diffusible monovalent co-ions of the first polarity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification