Silane-treated silica filter media

• US 7,850,012 B2
• Filed: 04/11/2008
• Issued: 12/14/2010
• Est. Priority Date: 10/01/2002
• Status: Expired due to Fees

• Current Assignee: Dow Corning Corporation (Dow, Inc.)
• Original Assignee: Dow Corning Corporation (Dow, Inc.), Danisco US, Inc. (International Flavors & Fragrances Incorporated)
• Inventors: Kollar, Csilla, Hayes, Keith, Steele, Landon M., Heng, Meng H., Gibson, Gary L., Revis, Anthony, Lane, Thomas H.
• Primary Examiner(s): Drodge; Joseph W
• Application Number:
  US12/101,743
• Publication Number:
  US 20080185333A1
• Time in Patent Office: 977 Days
• Field of Search: 210/496, 210/502.1, 210/506, 210/510.1, 210503-505, 210679-681, 210/198.2, 210/638, 210/639, 210/656, 106/2, 106/287.11, 106/287.12, 252/175, 252/184, 423/335, 423/336, 428/312.6, 428/331, 428/403, 428/404, 502/400, 502/407, 502401-406, 961/08, 961/53, 555/22, 555/24
• US Class Current: 210/502.1
• CPC Class Codes: B01D 15/361 Ion-exchange
• CPC Class Codes: B01D 15/3804 Affinity chromatography
• CPC Class Codes: B01J 20/103 comprising silica
• CPC Class Codes: B01J 20/14 Diatomaceous earth
• CPC Class Codes: B01J 20/286 Phases chemically bonded to a substrate, e.g. to silica or to polymers
• CPC Class Codes: B01J 20/3204 Inorganic carriers, supports or substrates
• CPC Class Codes: B01J 20/3242 Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
• CPC Class Codes: B01J 20/3244 Non-macromolecular compounds
• CPC Class Codes: B01J 20/3257 the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
• CPC Class Codes: B01J 20/3259 comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom
• CPC Class Codes: B01J 2220/4887 Residues, wastes, e.g. garbage, municipal or industrial sludges, compost, animal manure; fly-ashes
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Abstract

The present invention provides methods for separating one or more components of interest from a sample containing particulates and soluble materials. The method comprises the steps of: (a) filtering a sample through silica filter media whose surface silanol groups have reacted with one or more silanes, and (b) simultaneously capturing particulates and binding a soluble component to the silica filter media. The bound soluble component of interest is subsequently eluted from the silica filter media. In one embodiment of the invention, unwanted soluble materials are captured by the treated silica filter media and desired component of interest is recovered from the flow-through. In another embodiment, different components of interest are recovered from both the eluate and the flow-through. Preferred treated silica filter media are silane-treated rice hull ash or diatomaceous earth with functional quarternary ammonium group or functional sulphonate group. The present invention also provides silane-treated silica filter media.

Claims

1. Silane-treated silica filter media prepared by reacting the surface active group of silica filter media with silanes selected from the group consisting of 3-aminopropyltrimethoxysilane and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

3-trihydrosilylpropylmethylphosphonate, sodium salt and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride and (3-glycidoxypropyl)trimethoxysilane;

3-trihydrosilylpropylmethylphosphonate, sodium salt and bis-(2-hydroxyethyl)-3-aminopropyltriethoxysilane;

3-(N-styrylmethyl-2-aminoethylamino)-propyltrimethoxysilane hydrochloride and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

2-(trimethoxysilylethyl)pyridine and N-(3-triethoxysilylpropyl)-gluconamide;

N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride and N-(3-triethoxysilylpropyl)-gluconamide;

N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride and 2-hydroxy-4-(3-triethoxysilylpropoxy)-diphenylketone;

3-mercaptopropyltriethoxysilane and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

3-(triethoxysilyl)propylsuccinic anhydride and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

trimethoxysilylpropyl-ethylenediamine, triacetic acid, trisodium salt and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane;

2-(4-chlorosulfonylphenyl)-ethyltrichlorosilane and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane; and

2-(4-chlorosulfonylphenyl)-ethyltrichlorosilane and bis-(2-hydroxyethyl)-3-aminopropyltriethoxysilane, wherein the silica filter media are rice hull ash, oat hull ash or diamataceous earth.

2. The silane-treated silica filter media according to claim 1, wherein said silanes are 3-aminopropyltrimethoxysilane and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane.

3. The silane-treated silica filter media according to claim 1, wherein said silanes are 3-(N-styrylmethyl-2-aminoethylamino)-propyltrimethoxysilane hydrochloride and N-(triethoxysilylpropyl)-O-polyethylene oxide urethane.

4. Silane-treated silica filter media prepared by reacting the surface active group of silica filter media with one or more silanes selected from the group consisting of 2-hydroxy-4-(3-triethoxysilylpropoxy)-diphenlyketone, 2-(trimethoxysilylethyl)pyridine, N-(triethoxysilypropyl)-O-polyethylene oxide urethane, 3-(trimethoxysilyl)propyl methacrylate, 3-(triethoxysilyl)propylsuccinic anhydride, tris(3-trimethoxysilylpropyl)isocyanurate, bis[(3-methyldimethoxysilyl)propyl]-polypropylene oxide, 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane, N-(3-triethoxysilylpropyl)-4,5-dihydroimidazole, 2-(4-chlorosulfonylphenyl)-ethyltrichlorosilane, trimethoxysilylpropylisothiouronium chloride, N-(3-triethoxysilylpropyl)-gluconamide, N-(triethoxysilylpropyl)-4-hydroxy butyramide, and O-(propargyloxy)-N-(triethoxysilylpropyl)urethane, wherein the silica filter media are rice hull ash, oat hull ash, or diamotaceous earth.

5. The silane-treated silica filter media according to claim 4, wherein said silane is 2-hydroxy-4-(3-triethoxysilylpropoxy)-diphenylketone.

6. The silane-treated silica filter media according to claim 4, wherein said silane is N-(triethoxysilylpropyl)-O-polyethylene oxide urethane.

7. The silane-treated silica filter media according to claim 4, wherein said silane is 3-(triethoxysilyl)propylsuccinic anhydride.

8. The silane-treated silica filter media according to claim 4, wherein said silane is tris(3-trimethoxysilylpropyl)isocyanurate.

9. The silane-treated silica filter media according to claim 4, wherein said silane is bis[(3-methyldimethoxysilyl)propyl]-polypropylene oxide.

10. The silane-treated silica filter media according to claim 4, wherein said silane is N-(3-triethoxysilylpropyl)-gluconamide.

11. The silane-treated silica filter media according to claim 4, wherein said silane is N-(triethoxysilylpropyl)-4-hydroxybutyramide.

12. The silane-treated silica filter media according to claim 4, wherein said silane is 2-(trimethoxysilylethyl)pyridine.

13. The silane-treated silica filter media according to claim 4, wherein said silane is 3-(trimethoxysilyl)propyl methacrylate.

14. The silane-treated silica filter media according to claim 4, wherein said silane is 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane.

15. The silane-treated silica filter media according to claim 5, wherein said silane is N-(3-triethoxysilylpropyl)-4,5-dihydroimidazole.

16. The silane-treated silica filter media according to claim 4, wherein said silane is 2-(4-chlorosulfonylphenyl)-ethyltrichlorosilane.

17. The silane-treated silica filler media according to claim 4, wherein said silane is trimethoxysilylpropylisothiouronium chloride.

18. The silane-treated silica filter media according to claim 4, wherein said silane is O-(propargyloxy)-N-(triethoxysilylpropyl)urethane.