Apparatus and method for breathing pattern determination using a non-contact microphone

• US 7,850,619 B2
• Filed: 07/21/2005
• Issued: 12/14/2010
• Est. Priority Date: 07/23/2004
• Status: Expired due to Fees

• Current Assignee: 2breathe Technologies Ltd
• Original Assignee: InterCure Ltd.
• Inventors: Doron, Yoram, Gavish, Benjamin
• Primary Examiner(s): Marmor, II; Charles A
• Assistant Examiner(s): Natnithithadha; Navin
• Application Number:
  US11/572,483
• Publication Number:
  US 20080319333A1
• Time in Patent Office: 1,972 Days
• Field of Search: 600529-543, 600/586, 600/484
• US Class Current: 600/538
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/74 Details of notification to user or communication with user or patient indicating measured values G01D7/00; user input means input or output arrangements for computers G06F3/00
• CPC Class Codes: A61B 7/003 Detecting lung or respiration noise
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04

Abstract

A method is provided for analyzing respiration of a subject. Using a non-contact microphone, a raw signal indicative of air-flow sounds of the respiration is generated. The raw signal is analyzed to determine a first set of one or more parameters of the respiration. An algorithm is applied to the first set of parameters to derive a second set of one or more estimated parameters of the respiration that are not generally directly measurable in the raw signal. Other embodiments are also described.

Claims

1. Apparatus for analyzing respiration of a subject, comprising:

a non-contact microphone that does not contact the subject, adapted to generate a raw signal representing airflow sounds that are generated at the microphone by airflow of the respiration; and

a control unit, adapted to;

analyze the airflow sounds, by deriving an expiratory airflow sound signal from the raw signal, and analyzing the expiratory airflow sound signal, to determine a first set of one or more parameters of the respiration, and

apply an algorithm to the first set of parameters to derive a second set of one or more estimated parameters of the respiration, including an inspiration time of the subject.

2. The apparatus according to claim 1, wherein the control unit is adapted to set the inspiration time equal to a phenomenological function of the first set of one or more parameters.

3. The apparatus according to claim 1, wherein the first set of parameters includes a measure of breathing amplitude of the respiration, and wherein the control unit is adapted to analyze the airflow sounds by integrating the airflow sounds for a breath of the respiration to determine the measure of the breathing amplitude.

4. The apparatus according to claim 1, wherein the control unit is adapted to analyze a parameter selected from the group consisting of:

the first and second sets of parameters, to derive at least one additional breathing-related parameter of the subject selected from the group consisting of;

breathing amplitude, a geometrical property of airflow of the subject, a characteristic of the airflow indicative of pursed lips breathing, a characteristic of the breathing indicative of relaxed breathing, a characteristic of the breathing indicative of passive elastic recoil of lungs of the subject, a characteristic of breathing with effort, and a characteristic of breathing during which the lungs of the subject undergo a functional change.

5. The apparatus according to claim 1, comprising an output generator, wherein the control unit is adapted to drive the output generator to guide the subject to perform breathing in a plurality of respiration phases determined at least in part responsively to the inspiration time.

6. The apparatus according to claim 1, wherein the non-contact microphone comprises a non-contact microphone of a consumer electronics device capable of performing at least one function that does not facilitate analyzing respiration of the subject.

7. The apparatus according to claim 1, wherein the non-contact microphone is integrated into a medical device in fluid communication with respiration-related airflow of the subject.

8. The apparatus according to claim 7, wherein the medical device comprises a drug inhaler.

9. The apparatus according to claim 1, comprising an output generator, wherein the control unit is adapted to drive the output generator to generate a real-time indication for the subject that indicates whether expiration has been detected.

10. The apparatus according to claim 1, wherein the first set of parameters includes an active expiration time and a breathing period of the subject, and wherein the control unit is adapted to analyze the expiratory airflow sound signal to determine the active expiration time and the breathing period.

11. The apparatus according to claim 10, wherein the second set of parameters includes an amplitude of a non-expiratory portion of the respiration, and wherein the control unit is adapted to apply the algorithm to derive the amplitude of the non-expiratory portion of the respiration.

12. The apparatus according to claim 10, wherein the control unit is adapted to apply the algorithm to derive the inspiration time by:

determining whether a difference between the breathing period and the active expiration time is greater than or equal to a first function that is a function of the active expiration time,

responsively to a positive determination, setting the inspiration time equal to a second function that is a function of the difference, and

responsively to a negative determination, setting the inspiration time equal to a third function that is a function of the active expiration time.

13. The apparatus according to claim 12, wherein the control unit is adapted to determine whether the difference between the breathing period and the active expiration time is greater than or equal to the active expiration time.

14. The apparatus according to claim 12, wherein the control unit is adapted to, responsively to the positive determination, set the inspiration time equal to a value within plus or minus 20% of the difference.

15. The apparatus according to claim 14, wherein the control unit is adapted to, responsively to the positive determination, set the inspiration time equal to a value within plus or minus 10% of the difference.

16. The apparatus according to claim 12, wherein the second function includes a function of the difference and a phenomenological constant, and wherein the control unit is adapted to, responsively to the positive determination, set the inspiration time equal to the second function of the difference and the phenomenological constant.

17. The apparatus according to claim 16, wherein the control unit is adapted to determine the phenomenological constant at least in part responsively to at least one parameter of the first set of one or more parameters.

18. The apparatus according to claim 12, wherein the control unit is adapted to, responsively to the negative determination, set the inspiration time equal to a value within plus or minus 20% of the active expiration time.

19. The apparatus according to claim 18, wherein the control unit is adapted to, responsively to the negative determination, set the inspiration time equal to a value within plus or minus 10% of the active expiration time.

20. The apparatus according to claim 12, wherein the third function includes a function of the active expiration time and a phenomenological constant, and wherein the control unit is adapted to, responsively to the negative determination, set the inspiration time equal to the third function of the active inspiration time and the phenomenological constant.

21. The apparatus according to claim 20, wherein the control unit is adapted to determine the phenomenological constant at least in part responsively to at least one parameter of the first set of one or more parameters.

22. The apparatus according to claim 10, wherein the control unit is adapted to derive the inspiration time by setting the inspiration time equal to a function of a difference between the breathing period and the active expiration time.

23. The apparatus according to claim 22, wherein the control unit is adapted to set the inspiration time equal to a value within plus or minus 20% of the difference.

24. The apparatus according to claim 23, wherein the control unit is adapted to set the inspiration time equal to a value within plus or minus 10% of the difference.

25. The apparatus according to claim 22, wherein the function includes a function of the difference and a phenomenological constant, and wherein the control unit is adapted to set the inspiration time equal to the function of the difference and the phenomenological constant.

26. The apparatus according to claim 25, wherein the control unit is adapted to determine the phenomenological constant at least in part responsively to at least one parameter of the first set of one or more parameters.

27. The apparatus according to claim 10, wherein the control unit is adapted to derive the inspiration time by setting the inspiration time equal to a function of the active expiration time.

28. The apparatus according to claim 27, wherein the control unit is adapted to set the inspiration time equal to a value within plus or minus 20% of the active expiration time.

29. The apparatus according to claim 28, wherein the control unit is adapted to set the inspiration time equal to a value within plus or minus 10% of the active expiration time.

30. The apparatus according to claim 27, wherein the function includes a function of the active expiration time and a phenomenological constant, and wherein the control unit is adapted to set the inspiration time equal to the function of the active expiration time and the phenomenological constant.

31. The apparatus according to claim 30, wherein the control unit is adapted to determine the phenomenological constant at least in part responsively to at least one parameter of the first set of one or more parameters.

32. The apparatus according to claim 10, wherein the control unit is adapted to analyze the derived inspiration time to determine an amplitude of breathing during the inspiration time.

33. The apparatus according to claim 1, wherein the control unit is adapted to derive the expiratory airflow signal by digitizing the raw signal to generate a digital signal, performing spectral analysis on the digital signal to produce a frequency spectrum, and filtering the frequency spectrum to eliminate frequencies outside of a range of frequencies associated with expiratory airflow sounds.

34. The apparatus according to claim 33, wherein the control unit is adapted to filter the frequency spectrum by setting the range to be between a first frequency and a second frequency, the first frequency between 30 and 50 Hz, and the second frequency between 100 and 200 Hz.

35. The apparatus according to claim 33, comprising an output generator,

wherein the control unit is adapted to drive the output generator to guide the subject to perform breathing in a plurality of alternating inspiratory and expiratory respiration phases,

wherein the non-contact microphone is adapted to generate a raw calibration signal indicative of airflow sounds that are generated at the microphone by airflow of the respiration during the respiration phases, and

wherein the control unit is adapted to filter the frequency spectrum by:

digitizing the raw calibration signal to generate a digital calibration signal, and performing spectral analysis on the digital calibration signal to produce an inspiration frequency spectrum and an expiration frequency spectrum,

subtracting the inspiration spectrum from the expiration spectrum to obtain a net frequency spectrum,

determining a first frequency and a second frequency by analyzing the net frequency spectrum, and

setting the range to be between the first and second frequencies.

36. The apparatus according to claim 35, wherein the control unit is adapted to determine the first and second frequencies by:

setting the first frequency such that an area under a first portion of the net spectrum having a frequency less than the first frequency is less than a first percentage of a total area under the net spectrum, and

setting the second frequency such that an area under a second portion of the net spectrum having a frequency greater than the second frequency is less than a second percentage of the total area under the net spectrum.

37. The apparatus according to claim 1, wherein the control unit is adapted to derive the expiratory airflow sound signal from the raw signal by filtering the raw signal to eliminate frequencies outside of a range of frequencies associated with expiratory airflow sounds.

38. The apparatus according to claim 37, wherein the control unit is adapted to filter the raw signal by setting the range to be between a first frequency and a second frequency, the first frequency between 30 and 50 Hz, and the second frequency between 100 and 200 Hz.

39. The apparatus according to claim 1, wherein the control unit is adapted to analyze the airflow sounds by setting a detection threshold, and to derive the expiratory airflow sound signal by interpreting portions of the raw signal having a signal strength greater than the detection threshold as the expiratory airflow sound signal.

40. The apparatus according to claim 39, wherein the control unit is adapted to set the detection threshold at a level sufficient to reduce erratic peaks in the raw signal that are not associated with functional breathing.

41. The apparatus according to claim 39, wherein the control unit comprises a memory, and wherein the control unit is adapted to set the detection threshold by:

digitizing the raw signal to generate a digital signal having flow values at respective points in time, and buffering the flow values of the digital signal over a period of time in the memory,

transforming the buffered flow values into a histogram having a plurality of bins,

designating one of the bins having a greatest number of points as a maximum bin,

selecting two of the bins on opposite sides of the maximum bin,

setting a width of a noise band equal to a flow interval between the two bins, and

setting the detection threshold responsively to a flow value of the maximum bin and the width of the noise band.

42. The apparatus according to claim 41, wherein the control unit is adapted to set the detection threshold equal to the flow value of the maximum bin plus a product of a constant and the width of the noise band.

43. The apparatus according to claim 1, wherein the control unit is adapted to detect sleep-disordered breathing by analyzing at least one parameter selected from the group consisting of:

the first set of parameters and the second set of estimated parameters.

44. The apparatus according to claim 43, wherein the sleep-disordered breathing includes breathing associated with apnea, and wherein the control unit is adapted to detect the apnea.

45. The apparatus according to claim 43, wherein the sleep-disordered breathing includes breathing associated with sudden infant death syndrome (SIDS), and wherein the control unit is adapted to detect the SIDS.

46. The apparatus according to claim 1, further comprising an output generator, wherein the control unit is adapted to drive the output generator to generate an output for guiding the subject'"'"'s breathing in response to the first and second parameters.

47. The apparatus according to claim 35, wherein the control unit is adapted to detect sleep-disordered breathing by analyzing at least one parameter selected from the group consisting of:

the first set of parameters and the second set of estimated parameters.

48. The apparatus according to claim 47, wherein the control unit is adapted to drive the output generator in response to detecting the sleep-disordered breathing.