Medicament microdevice delivery system, cartridge and method of use
First Claim
1. A dermal delivery device comprising:
- a housing comprising a chamber, an inlet port communicating with said chamber, and an outlet port communicating with said chamber;
a cartridge, wherein said cartridge comprises a passage, a fluid receiving opening and a fluid discharge opening, both openings communicating with said passage;
wherein said cartridge comprises opposed ends and said ends have convex surfaces and each end is sealed by a burstable membrane comprised of a polyolefin film having a thickness of between 0.3 and 1.5 mils stretched taut over each of said convex surfaces at said opposed ends of said cartridge and bonded to said convex surfaces, sealing said passage wherein said polyolefin film has a burst pressure of less than 5 atmospheres;
a dry powdered medicament retained by said burstable membranes within said cartridge;
a microdelivery device sized to penetrate into the intradermal space;
wherein at least one of said burstable membranes is sealingly attached to at least one of said ports; and
an adapter communicating with said inlet port and adapted to communicate with a source of a fluid diluent.
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Accused Products
Abstract
A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.
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Citations
23 Claims
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1. A dermal delivery device comprising:
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a housing comprising a chamber, an inlet port communicating with said chamber, and an outlet port communicating with said chamber; a cartridge, wherein said cartridge comprises a passage, a fluid receiving opening and a fluid discharge opening, both openings communicating with said passage;
wherein said cartridge comprises opposed ends and said ends have convex surfaces and each end is sealed by a burstable membrane comprised of a polyolefin film having a thickness of between 0.3 and 1.5 mils stretched taut over each of said convex surfaces at said opposed ends of said cartridge and bonded to said convex surfaces, sealing said passage wherein said polyolefin film has a burst pressure of less than 5 atmospheres;a dry powdered medicament retained by said burstable membranes within said cartridge; a microdelivery device sized to penetrate into the intradermal space; wherein at least one of said burstable membranes is sealingly attached to at least one of said ports; and an adapter communicating with said inlet port and adapted to communicate with a source of a fluid diluent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification