Expandable medical device for delivery of beneficial agent

• US 7,850,728 B2
• Filed: 03/06/2006
• Issued: 12/14/2010
• Est. Priority Date: 10/16/2000
• Status: Expired due to Fees

• Current Assignee: Innovational Holdings, LLC
• Original Assignee: Innovational Holdings, LLC
• Inventors: Shanley, John F.
• Primary Examiner(s): Willse; David H
• Assistant Examiner(s): Blanco; Javier G
• Application Number:
  US11/368,957
• Publication Number:
  US 20060149357A1
• Time in Patent Office: 1,744 Days
• Field of Search: 623/1.42, 623 115- 117, 623/1.34, 623/1.39, 623/1.43, 623/1.46
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir

Abstract

An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, and the plurality of struts each having a strut width in a circumferential direction. At least one of the plurality of struts includes at least one opening extending at least partially though a thickness of the strut. A beneficial agent may be loaded into the opening within the strut. The expandable medical device may further include a plurality of ductile hinges formed between the elongated struts, the ductile hinges allowing the cylindrical device to be expanded or compressed from the first diameter to the second diameter by deformation of the ductile hinges.

Claims

1. An expandable medical device comprising:

a cylindrical tube, with a network of struts therein, said network allowing the cylindrical tube to be expanded or compressed from a first diameter to a second diameter;

a plurality of openings in the struts, said openings extending though a thickness of said struts, so as to define a plurality of through-openings therein, said through-openings formed in at least two different shapes, said through-openings being non-deforming;

a beneficial agent loaded within the plurality of openings; and

wherein the network of struts are substantially rigid struts interconnected by deformable struts; and

wherein the substantially rigid struts experience substantially no plastic deformation during expansion or compression from the first diameter to the second diameter; and

wherein said beneficial agent defines a first beneficial agent, and further comprising a surface coating of a second beneficial agent different from said first beneficial agent on said expandable medical device; and

wherein the plurality of openings are formed in the substantially rigid struts, and the deformable struts are devoid of any openings.

2. The expandable medical device according to claim 1, wherein said beneficial agent includes antiproliferatives.

3. The expandable medical device according to claim 1, wherein said beneficial agent includes antithrombins.

4. The expandable medical device according to claim 1, wherein said beneficial agent includes at least one of large molecules, microspheres, beneficial agents within a biodegradable polymer carrier, and cells, said plurality of openings forming a protected receptor for loading said beneficial agent therein.

5. The expandable medical device according to claim 1, wherein said at least one cylindrical tube includes two cylindrical tubes interconnected by a bridging element.

6. The expandable medical device according to claim 1, wherein the expandable medical device is formed of Nitinol.

7. The expandable medical device according to claim 1, wherein the expandable medical device is formed of stainless steel.