Method and device for monitoring the supply of substitution fluid during an extracorporeal blood treatment

• US 7,850,856 B2
• Filed: 11/22/2002
• Issued: 12/14/2010
• Est. Priority Date: 12/05/2001
• Status: Expired due to Term

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Inventors: Zhang, Wei, Wamsiedler, Ralf
• Primary Examiner(s): KIM, SUN U
• Application Number:
  US10/498,034
• Publication Number:
  US 20050065459A1
• Time in Patent Office: 2,944 Days
• Field of Search: 210/85, 210/90, 210/97, 210/143, 210/258, 210/321.65, 210/416.1, 210/645, 210/646, 210/739, 210/741, 210/929, 604/4.01, 604/5.01, 604/6.09, 604/6.11, 604/28, 604/65, 604/67
• US Class Current: 210/741
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3434 with pre-dilution and post-dilution
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3465 using dialysate as substitution fluid
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 1/3656 Monitoring patency or flow at connection sites; Detecting disconnections
• CPC Class Codes: A61M 5/16859 Evaluation of pressure response, e.g. to an applied pulse
• CPC Class Codes: Y10S 210/929 Hemoultrafiltrate volume measurement or control processes

Abstract

The invention relates to a method for monitoring the supply of substitution liquid during an extracorporeal blood treatment and to an extracorporeal blood treatment unit equipped with a device for monitoring the supply of substitution liquid. The monitoring of the supply of substitution liquid is based on the measurement of pressure waves, which are generated by the substitution liquid pump, in the extracorporeal blood circulation system. A disturbance in the supply of substitution liquid is inferred when the amplitude of the pressure waves exceeds a predetermined limit value. The amplitude of the pressure waves is preferably monitored in the venous blood line.

Claims

1. A method for monitoring the supply of a substitution fluid during an extracorporeal blood treatment, said method comprising:

providing an extracorporeal blood circuit comprising;

a first chamber of a dialyser, wherein the dialyser is subdivided by a semipermeable membrane into the first chamber and a second chamber;

providing a fluid system comprising;

the second chamber of the dialyser,

a substitution fluid line connecting to the extracorporeal blood circuit upstream or downstream of the dialyser,

a substituate pump on the substitution fluid line to deliver the substitution fluid from the fluid system to the extracorporeal blood circuit upstream or downstream of the dialyser, and

a pressure sensor in the fluid system for measuring pressure waves generated by the substituate pump in the upstream direction of the substitution fluid line;

generating a plurality of pressure waves with the substituate pump;

measuring the pressure waves in the fluid system with the pressure sensor;

converting the measured pressure waves into an electrical signal having an amplitude;

comparing the amplitude to a preset limiting value; and

determining there is an interruption of the supply of the substitution fluid when the amplitude of the pressure waves exceeds the preset limiting value.

2. The method according to claim 1, wherein the substitution fluid is fed downstream of the dialyser.

3. The method according to claim 1, wherein the substitution fluid is fed upstream of the dialyser.

4. The method according to claim 1, further comprising:

monitoring a pumping rate of the substituate pump, wherein an interruption of the supply of the substitution fluid is indicated by the amplitude of the pressure waves exceeding a preset limiting value only if the pumping rate lies between a second preset limiting value and a third preset limiting value.

5. The method according to claim 1, further comprising:

filtering the pressure signal with a bandpass, wherein the amplitude of the filtered pressure signal is compared with the preset limiting value.

6. The method according to claim 1, further comprising:

emitting at least one of an acoustic alarm and an optical alarm when the preset limiting value is exceeded.

7. The method according to claim 1, wherein the substituate pump is a roller pump.

8. The method according to claim 1, wherein the monitoring of the supply of the substitution fluid occurs continuously during the extracorporeal blood treatment.

9. The method according to claim 1, wherein the monitoring of the supply of the substitution fluid takes place continuously during the operation of the substituate pump.

10. The method of claim 1, wherein the preset limiting value of the amplitude is 1.5 to 2.5 times a normal value of the amplitude.

11. The method of claim 1, wherein the preset limiting value of the amplitude is 1.5 times a normal value of the amplitude.

12. The method of claim 1, wherein the preset limiting value of the amplitude is 2 times a normal value of the amplitude.

13. The method of claim 3, wherein the fluid system further comprises a dialysis fluid supply line connecting to the second chamber of the dialyser, and wherein the pressure sensor is located on the dialysis fluid supply line.

14. An apparatus for extracorporeal blood treatment comprising:

an extracorporeal blood circuit including a first chamber of a dialyser, wherein the dialyser is subdivided by a semipermeable membrane into the first chamber and a second chamber;

a fluid system including comprising;

the second chamber of the dialyser;

a substitution fluid line connecting to the extracorporeal blood circuit upstream or downstream of the dialyser;

a substituate pump generating pressure waves arranged in the substitution fluid line to deliver the substitution fluid from the fluid system to the extracorporeal blood circuit upstream or downstream of the dialyser; and

a monitoring device for monitoring a supply of substitution fluid from the fluid system into the extracorporeal blood circuit, wherein the monitoring device includes means in the fluid system for measuring pressure waves generated by the substituate pump in the upstream direction of the substitution fluid line and for monitoring the amplitude of the pressure waves in the fluid system propagated by the substituate pump in the upstream direction of the substitution fluid line, and means for evaluating the amplitude of the pressure waves, wherein the monitoring device is designed such that an interruption of the supply of substitution fluid is indicated by the amplitude of the pressure waves exceeding a preset limiting value.

15. The apparatus according to claim 14, wherein the means for monitoring the amplitude of the pressure waves generated by the substituate pump are arranged in the fluid system upstream of the dialyser.

16. The apparatus according to claim 14, further comprising:

means for monitoring a pumping rate of the substituate pump, wherein an interruption of the supply of the substitution fluid is indicated by the amplitude of the pressure waves exceeding a preset limiting value only if the pumping rate lies between a second preset limiting value and a third preset limiting value.

17. The apparatus according to claim 14, wherein the means for monitoring the amplitude of the pressure waves generated by the substituate pump include a pressure sensor for measuring a pressure, a pressure signal sensor for generating a pressure signal dependent on the measured pressure, and a bandpass filter for filtering the pressure signal.

18. The apparatus according to claim 14, further comprising:

an alarm unit for generating at least one of an acoustic alarm and an optical alarm when the preset limiting value is exceeded.

19. The apparatus according to claim 14, wherein the substituate pump is a roller pump.

20. The apparatus of claim 14, wherein the fluid system further comprises a dialysis fluid supply line connecting to the second chamber of the dialyser, and wherein the means for monitoring the amplitude of the pressure waves is located on the dialysis fluid supply line.

21. A method for monitoring the supply of a substitution fluid during an extracorporeal blood treatment, said method comprising:

providing an extracorporeal blood circuit comprising;

a first chamber of a dialyser having an inlet and an outlet, wherein the dialyser is subdivided by a semipermeable membrane into the first chamber and a second chamber,

an arterial blood line connected to the inlet of the first chamber,

a venous blood line connected to the outlet of the first chamber, and

a pressure sensor;

providing a fluid system comprising;

the second chamber of the dialyser,

a substitution fluid line connecting to the extracorporeal blood circuit upstream or downstream of the dialyser, and

a substituate pump on the substitution fluid line to deliver the substitution fluid from the fluid system to the extracorporeal blood circuit upstream or downstream of the dialyser;

generating a plurality of pressure waves with the substituate pump;

measuring the pressure waves in the extracorporeal blood circuit, said pressure waves generated by the substituate pump in the substitution fluid line;

converting the measured pressure waves into an electrical signal having an amplitude;

comparing the amplitude to a preset limiting value; and

determining there is an interruption of the supply of the substitution fluid when the amplitude of the pressure waves exceeds the preset limiting value.

22. The method according to claim 21, further comprising:

monitoring a pumping rate of the substituate pump, wherein an interruption of the supply of the substitution fluid is indicated by the amplitude of the pressure waves exceeding a preset limiting value only if the pumping rate lies between a second preset limiting value and a third preset limiting value.

23. The method according to claim 21, further comprising:

emitting at least one of an acoustic alarm and an optical alarm when the preset limiting value is exceeded.

24. The method according to claim 21, further comprising:

filtering the pressure signal with a bandpass, wherein the amplitude of the filtered pressure signal is compared with the preset limiting value.

25. The method of claim 21, wherein the pressure sensor is located on the venous blood line.

26. An apparatus for extracorporeal blood treatment comprising:

an extracorporeal blood circuit comprising;

a first chamber of a dialyser, wherein the dialyser is subdivided by a semipermeable membrane into the first chamber and a second chamber,

an arterial blood line connected to the inlet of the first chamber, and

a venous blood line connected to the outlet of the first chamber,

a fluid system comprising;

the second chamber of the dialyser;

a substitution fluid line connecting to the extracorporeal blood circuit upstream or downstream of the dialyser,

a substituate pump for generating pressure waves arranged in the substitution fluid line; and

a monitoring device for monitoring a supply of substitution fluid from the fluid system into the extracorporeal blood circuit, wherein the monitoring device includes means for monitoring the amplitude of the pressure waves in the extracorporeal blood circuit generated by the substituate pump, and means for evaluating the amplitude of the pressure waves, wherein the monitoring device is designed such that an interruption of the supply of substitution fluid is indicated by the amplitude of the pressure waves exceeding a preset limiting value.

27. The apparatus according to claim 26, further comprising:

means for monitoring a pumping rate of the substituate pump, wherein an interruption of the supply of the substitution fluid is indicated by the amplitude of the pressure waves exceeding a preset limiting value only if the pumping rate lies between a second preset limiting value and a third preset limiting value.

28. The apparatus according to claim 26, wherein the means for monitoring the amplitude of the pressure waves generated by the substituate pump include a pressure sensor for measuring a pressure, a pressure signal sensor for generating a pressure signal dependent on the measured pressure, and a bandpass filter for filtering the pressure signal.

29. The apparatus according to claim 26, further comprising:

an alarm unit for generating at least one of an acoustic alarm and an optical alarm when the preset limiting value is exceeded.

30. The apparatus of claim 26, wherein the means for monitoring the amplitude of the pressure waves is located on the venous blood line.