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Methods and compositions for repair of cartilage using an in vivo bioreactor

  • US 7,850,983 B2
  • Filed: 02/05/2007
  • Issued: 12/14/2010
  • Est. Priority Date: 02/07/2006
  • Status: Active Grant
First Claim
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1. A method of repairing damaged cartilage in a joint of an individual, comprising delivering a device to the respective joint of the individual, wherein the device comprises:

  • cells/scaffold composition; and

    an encapsulating device that comprises;

    a first membrane having an inside and an outside;

    a second membrane having an inside and an outside, wherein the first membrane is encapsulated inside the second membrane;

    a first volume disposed inside the first membrane;

    a second volume that is disposed outside the first membrane and that is disposed inside the second membrane; and

    a structure for adding fluid to the second volume, removing fluid from the second volume, or both,wherein the cells/scaffold composition is disposed inside the first membrane and the first membrane has the following characteristics;

    semi-permeable;

    biocompatible;

    biodegradable; and

    resorbable,wherein the second membrane has the following characteristics;

    biocompatible;

    hermetic to fluid;

    permeable to oxygen;

    resorbable;

    biodegradable; and

    expandable.

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