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Nucleic acid mediated electron transfer

  • US 7,851,146 B2
  • Filed: 10/23/2002
  • Issued: 12/14/2010
  • Est. Priority Date: 12/10/1993
  • Status: Expired due to Fees
First Claim
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1. A method of detecting a target sequence, comprisinga) hybridizing a target nucleic acid comprising a first and second domain to a first single stranded nucleic acid covalently attached to a first electron transfer moiety comprising an electrode, wherein said first single stranded nucleic acid hybridizes to said first domain;

  • b) hybridizing a second single stranded nucleic acid to said second domain to form a hybridization complex comprising said target nucleic acid, said first single stranded nucleic acid, and said second single stranded nucleic acid, wherein said hybridization complex further comprises a second electron transfer moiety; and

    c) detecting electron transfer between said second electron transfer moiety and said electrode as an indicator of the presence of said target nucleic acid in said hybridization complex.

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