Biomarkers of mild cognitive impairment and alzheimer's disease
First Claim
1. A method for aiding diagnosis of mild cognitive impairment or Alzheimer'"'"'s Disease in an individual, comprising:
- (a) obtaining a sample of cerebrospinal fluid from the individual;
(b) measuring an amount of and/or a concentration of a protein biomarker complex that comprises transthyretin and prostaglandin-H2 isomerase in said sample; and
(c) comparing the measured amount and/or concentration to a reference value, wherein a greater measured amount and/or concentration of the biomarker complex as compared to the reference value is indicative of a higher likelihood that the individual is afflicted with mild cognitive impairment or Alzheimer'"'"'s disease, thereby aiding diagnosis of mild cognitive impairment or Alzheimer'"'"'s disease in the individual.
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Abstract
A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and correlating the measurement with mild cognitive impairment or Alzheimer'"'"'s disease status. The biomarkers include those that comprise at least one of a transthyretin protein and/or a prostaglandin-H2 D-isomerase protein, and at least one second, different protein selected from a transthyretin, prostaglandin-H2 D-isomerase, beta-2-microglobulin, cystatin C, superoxide dismutase [Cu—Zn], plasma retinol-binding protein, phosphatidylethanolamine-binding protein, carbonic anhydrase 2, prostaglandin-H2 D-isomerase, and/or serotransferrin protein.
31 Citations
6 Claims
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1. A method for aiding diagnosis of mild cognitive impairment or Alzheimer'"'"'s Disease in an individual, comprising:
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(a) obtaining a sample of cerebrospinal fluid from the individual; (b) measuring an amount of and/or a concentration of a protein biomarker complex that comprises transthyretin and prostaglandin-H2 isomerase in said sample; and (c) comparing the measured amount and/or concentration to a reference value, wherein a greater measured amount and/or concentration of the biomarker complex as compared to the reference value is indicative of a higher likelihood that the individual is afflicted with mild cognitive impairment or Alzheimer'"'"'s disease, thereby aiding diagnosis of mild cognitive impairment or Alzheimer'"'"'s disease in the individual. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification