Osmotic reaction detector for monitoring biological and non-biological reactions
First Claim
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1. An osmotic cell system for monitoring reactivity in reactions between a first material of interest and a second material of interest, said osmotic cell system comprising:
- a first well for containing a reference solution;
a second well having substantially the same physical dimensions as the first well and for containing a reaction mixture comprising at least first and second materials of interest;
a semi-permeable membrane separating said first well from said second well; and
a pressure sensor for measuring changes in osmotic pressure in said first well and said second well after allowing said first and second wells to reach equilibrium, wherein said pressure sensor is a deflectable diaphragm operatively associated only with the first well containing the reference solution.
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Abstract
A method and apparatus for measuring the presence or absence of reaction between a first and second material of interest by measuring osmotic pressure changes in a reaction cell. The reaction cell is capable of measuring the small changes in pressure that occur due to osmotic pressure shifts during a catalytic or binding reaction at species concentrations down to approximately 10−7 M.
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Citations
18 Claims
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1. An osmotic cell system for monitoring reactivity in reactions between a first material of interest and a second material of interest, said osmotic cell system comprising:
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a first well for containing a reference solution; a second well having substantially the same physical dimensions as the first well and for containing a reaction mixture comprising at least first and second materials of interest; a semi-permeable membrane separating said first well from said second well; and a pressure sensor for measuring changes in osmotic pressure in said first well and said second well after allowing said first and second wells to reach equilibrium, wherein said pressure sensor is a deflectable diaphragm operatively associated only with the first well containing the reference solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification