Methods for nerve repair
First Claim
1. A method for increasing axon growth across a site of damage in a damaged nerve of the peripheral nervous system, wherein said damaged nerve is partially or completely severed at the site of damage, and has a portion proximal to the site of damage and a portion distal to the site of damage, and wherein said method comprises:
- applying at least one chondroitin sulfate proteoglycan-degrading (CSPG-degrading) enzyme selected from the group consisting of chondroitinase ABC, chondroitinase A, chondroitinase C and chondroitinase AC to the damaged nerve in vivo, andcoapting the proximal portion with the distal portion;
wherein axon growth from the proximal portion to the distal portion, across the site of damage, is increased compared to axon growth in a damaged nerve to which a CSPG-degrading enzyme has not been applied.
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Accused Products
Abstract
The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also pertains to kits for nerve repair.
37 Citations
41 Claims
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1. A method for increasing axon growth across a site of damage in a damaged nerve of the peripheral nervous system, wherein said damaged nerve is partially or completely severed at the site of damage, and has a portion proximal to the site of damage and a portion distal to the site of damage, and wherein said method comprises:
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applying at least one chondroitin sulfate proteoglycan-degrading (CSPG-degrading) enzyme selected from the group consisting of chondroitinase ABC, chondroitinase A, chondroitinase C and chondroitinase AC to the damaged nerve in vivo, and coapting the proximal portion with the distal portion; wherein axon growth from the proximal portion to the distal portion, across the site of damage, is increased compared to axon growth in a damaged nerve to which a CSPG-degrading enzyme has not been applied. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification