Use of pyrimidinedione derivative for preventing or treating hepatitis C

• US 7,851,479 B2
• Filed: 02/08/2007
• Issued: 12/14/2010
• Est. Priority Date: 02/10/2006
• Status: Expired due to Fees

• Current Assignee: Samjin Pharmaceutical Company Limited
• Original Assignee: Samjin Pharmaceutical Company Limited
• Inventors: Lee, Young-Hee, Lee, Jae-Woong, Kim, Hyun-Tae, Cho, Eui-Hwan, Joo, Jeong-Ho, Lee, Sun-Hwan, Kwon, Ho-Seok, Myung, Hyun-Nam, Chung, Sun-Gan
• Primary Examiner(s): Kwon; Brian-Yong S
• Application Number:
  US12/278,659
• Publication Number:
  US 20090023764A1
• Time in Patent Office: 1,405 Days
• Field of Search: None
• US Class Current: 514/274
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/14 for RNA viruses

Abstract

A pyrimidinedione derivative of formula (I) or a pharmaceutically acceptable salt thereof exhibits excellent inhibitory activity against hepatitis C virus.

Claims

1. A method for treating hepatitis C in a mammal in need of such treatment, which comprises administering a pyrimidinedione compound of the following formula (I) or a pharmaceutically acceptable salt thereof to the mammal:

2. The method of claim 1, wherein R₁ is C₃˜

C₆ cycloalkyl, cyclopentenyl or hydroxymethylcyclopentenyl.

3. The method of claim 1, wherein the pyrimidinedione compound is:

1-cyclopropylmethyl-6-(3,5-dimethyl-phenylsulfanyl)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-cyclopropylmethyl-6-(3,5-dimethyl-phenoxy)-5-ethyl-1H-pyrimidine-2,4-dione;

1-cyclobutylmethyl-6-(3,5-dimethyl-phenylsulfanyl)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-cyclopentylmethyl-6-(3,5-dimethyl-phenylsulfanyl)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-cyclopent-1-enylmethyl-6-(3,5-dimethyl-phenylsulfanyl)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-cyclopent-1-enylmethyl-6-(3,5-dimethyl-phenoxy)-5-ethyl-1H-pyrimidine-2,4-dione;

1-cyclopent-1-enylmethyl-6-(3,5-dimethyl-phenoxy)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-cyclopent- 1-enylmethyl-6-(3 5 -dimethyl-benzoyl)-5-ethyl-1H-pyrimidine-2,4-dione;

1-cyclopent-1-enylmethyl-6-(3,5-dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-cyclopent-3-enylmethyl-5-isopropyl-6-phenylsulfanyl-1H-pyrimidine-2,4-dione;

1-cyclohexylmethyl-6-(3,5-dimethyl-phenylsulfanyl)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-(2-cyclopentyl-ethyl)-6-(3,5-dimethyl-phenylsulfanyl)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-(2-cyclopent-2-enyl-ethyl)-6-(3,5-dimethyl-phenoxy)-5-isopropyl-1H-pyrimidine-2,4-dione;

1-(2-cyclopent-3-enyl-ethyl)-6-(3,5-dimethyl-phenylsulfanyl)-5-ethyl-1H-pyrimidine-2,4-dione;

1-(2-cyclopent-2-enyl-ethyl)-6-(3,5-dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione;

or 6-(3,5-dimethyl-benzoyl)-5-ethyl-1-(4-hydroxymethyl-cyclopent-1-enylmethyl)-1H-pyrimidine-2,4-dione.