Apparatus and method for imaging the eye

• US 7,854,510 B2
• Filed: 10/15/2009
• Issued: 12/21/2010
• Est. Priority Date: 10/16/2008
• Status: Active Grant

• Current Assignee: NeuroVision Imaging, LLC
• Original Assignee: NeuroVision Imaging, LLC
• Inventors: Verdooner, Steven Roger, Leach, Steven
• Primary Examiner(s): DANG, HUNG XUAN
• Application Number:
  US12/580,247
• Publication Number:
  US 20100097573A1
• Time in Patent Office: 432 Days
• Field of Search: 351/214, 351/206, 351/221, 351/209, 351/210, 351/211, 351/212, 351/213, 351/246
• US Class Current: 351/214
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B

Abstract

A slit lamp mounted eye imaging device for viewing wide field and/or magnified views of the retina or the anterior segment through an undilated or dilated pupil. The apparatus images posterior and anterior segments of the eye, and sections/focal planes in between and contains an illumination system that uses one or more LEDs, shifting optical elements, and/or aperture stops where the light can be delivered into the optical system on optical axis or off axis from center of optical system and return imaging path from the retina, thereby creating artifacts in different locations on retina. Image processing is employed to detect and eliminate artifacts from images. The device is well suited for retinal imaging through an undilated pupil, non-pharmacologically dilated, or a pupil as small as 2 mm. Two or more images with reflection artifacts can be created and subsequently recombined through image processing into a composite artifact-free image.

Claims

1. Apparatus for imaging the posterior and anterior segments of a person'"'"'s eye comprising:

a light source;

an optical system having optical elements that can be shifted for delivering light from said light source either on optical axis or slightly off axis from the center of the optical system and return imaging path from the retina or other eye features;

control means coupled to sequentially turn said light source on and off in synchronization with image capture under each condition; and

means for shifting at least one of said optical elements in said optical system;

wherein two images having specular reflection artifacts located in two anatomically different areas of each sequentially acquired image of said segment of the eye are created, and whereby the artifacts in each image are detected by image processing;

wherein images with artifacts are combined with one or more images to create a composite image or video stream that is free of artifacts;

wherein only clear well-focused image sections are combined from one or more images to create a composite image.

2. The apparatus of claim 1 wherein said light source is laterally shifted.

3. The apparatus of claim 2 wherein said light source is shifted and also rotated.

4. The apparatus of claim 3 wherein said light source has at least two or more light sources that are sequentially triggered.

5. The apparatus of claim 3 wherein the alternate illuminating and imaging paths enter the eye pupil at an angle compared to the optical center axis but parallel to the center of the optical system.

6. The apparatus of claim 5 wherein the angular separation of the overlapping light sources and imaging paths are of variable size position and shape depending upon pupil size and can be manually or automatically adjusted based on pupil size.

7. The apparatus of claim 6 wherein a spatial light modulator is provided for positioning and shaping the illumination beam according to the sensed location and dimensions of the pupil.

8. The apparatus of claim 6 wherein an IR or near IR filter is provided for alignment mode and flipped out to allow other spectral wavelengths to pass and subsequent image capture.

9. The apparatus of claim 6 wherein a flexible eye cup of flexible material positioned to surround a person'"'"'s eye to create a darkened environment and to hold a person'"'"'s eyelids open during eye imaging;

wherein the eye cup contains a hardened portion at the 12 o'"'"'clock and/or 6 o'"'"'clock positions and presses in and upward and downward 45 degree angular direction, that is used to hold eyelids open.

10. The apparatus in claim 6 wherein the focus of the device is varied and stepped to allow capture at multiple focal planes in the eye, and recombined into a single plenoptic image and movie.

11. The apparatus in claim 6 where the focus of the device is varied by a series of microlenses of differing focal lengths is placed on an image sensor and images subsequently captured at multiple focal lengths.

12. The apparatus in claim 11 that attaches to an existing slit lamp or fundus camera and utilizes a portion of said imaging elements and system for image capture and image processing.

13. The apparatus in claim 12 that is fitted with light sources and filters for procedures of color fundus imaging, fluorescein angiography, red-fee-red, blue, ICG angiography, all wavelengths of autofluorescence, functional imaging, lens, cornea and other anterior segment imaging, tear film imaging, optical coherence tomography, and ultra-wide field imaging, and as a guidance system for various treatment modalities.

14. The apparatus of claim 1 wherein said light source is rotated.

15. A method of imaging the posterior and anterior segments of a person'"'"'s eye comprising the steps of:

providing a light source;

providing an optical system having optical elements that can be shifted for delivering light from said light source either on optical axis or slightly off axis from the center of the optical system and return imaging path from the retina or other eye features;

providing control means to sequentially turn said light source on and off in synchronization with image capture under each condition; and

providing means for shifting at least one of said optical elements in said optical system;

wherein two images having specular reflection artifacts located in two anatomically different areas of each sequentially acquired image of said segment of the eye are created, and whereby the artifacts in each image are detected by image processing;

wherein images with artifacts are combined with one or more images to create a composite image or video stream that is free of artifacts;

wherein only clear well-focused image sections are combines from one or more images to create a composite image.

16. The method of claim 15 wherein said light source is laterally shifted.

17. The method of claim 16 wherein said light source is shifted and also rotated.

18. The method of claim 17 wherein said light source has at least two or more light sources that are sequentially triggered.

19. The method of claim 18 wherein the alternate illuminating and imaging paths enter the eye pupil at an angle compared to the optical center axis but parallel to the center of the optical system.

20. The method of claim 19 wherein the angular separation of the overlapping light sources and imaging paths are of variable size position and shape depending upon pupil size, and can be manually or automatically adjusted based on pupil size.

21. The method of claim 20 wherein a spatial light modulator is provided for positioning and shaping the illumination beam according to the sensed location and dimensions of the pupil.

22. The method of claim 21 wherein an IR or near IR filter is provided for alignment mode and flipped out to allow other spectral wavelengths to pass and subsequent image capture.

23. The method of claim 22 wherein a flexible eye cup of flexible material positioned to surround a person'"'"'s eye to create a darkened environment and to hold a person'"'"'s upper eyelid open during an eye imaging wherein the eye cup contains a hardened portion at the 12 o'"'"'clock and/or 6 o'"'"'clock positions and presses in and upward and downward 45 degree angular direction, that is used to hold eyelids open.

24. The method of claim 23 wherein the focus of the device is varied and stepped to allow capture at multiple focal planes in the eye, and recombined into a single plenoptic image and movie.

25. The method of claim 24 wherein the focus of the device is varied by a series of microlenses of differing focal lengths is placed on an image sensor and images subsequently captured at multiple focal lengths.

26. The method of claim 25 wherein attaching to an existing slit lamp or fundus camera and utilizes a portion of said imaging elements and system for image capture and image processing.

27. The method of claim 26 fitting with light sources and filters for procedures of color fundus imaging, fluorescein angiography, red-free, blue, red, ICG angiography, all wavelengths of autofluorescence, functional imaging, lens, cornea and other anterior segment imaging, tear film imaging, optical coherence tomography, and ultra-wide field imaging, and as a guidance system for various treatment modalities.

28. The method of claim 27 containing a lateral shift of optical elements to create a three dimensional stereo pair of images.

29. The method of claim 28 containing an anti-shake/image stabilization algorithm for removal of eye movement and operator movement.

30. The method of claim 29 automatically building a wide field panoramic image during or just after image capture, building upon the previously captured images, to create a large panoramic view of the retina or other eye anatomy and features.

31. The method of claim 30 containing a means for controlling patient fixation and thereby creating images with artifacts in different anatomical locations and thereby combing said images into artifact-free composite images.

32. The method of claim 15 wherein said light source is rotated.