Catheter for the delivery of therapeutic agents to tissues

• US 7,854,743 B2
• Filed: 07/21/2005
• Issued: 12/21/2010
• Est. Priority Date: 11/04/1997
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Barry, James J., Wang, Lixiao, Palasis, Maria, Harrison, Kent D., Ellis, Louis, Hendrickson, Gary L.
• Primary Examiner(s): TRUONG, KEVIN THAO
• Application Number:
  US11/185,801
• Publication Number:
  US 20050256450A1
• Time in Patent Office: 1,979 Days
• Field of Search: 606/29, 606/30, 606/31, 606/41, 606/45, 606/102, 606/167, 606/170, 606/174, 606/181, 606/184, 606/185
• US Class Current: 606/167
• CPC Class Codes: A61B 17/3468 for implanting or removing devices, e.g. prostheses, implants, seeds, wires devices for implanting seeds A61M37/0069
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/320084 Irrigation sleeves
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61B 2018/1425 Needle
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61L 2300/258 Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/64 Animal cells
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

A catheter for placement of an in situ implant is provided. This catheter may include a first elongate shaft having a proximal end and a distal end, a second elongate shaft having a proximal end and a distal end, a first sharpened distal tip disposed at the distal end of the first shaft and a second sharpened distal tip disposed at the distal end of the second shaft. The first shaft and the second shaft may also be secured to one another at the distal end of the first shaft according to the invention. Still further, according to other teachings, the first sharpened distal tip may extend beyond the second sharpened distal tip in a catheter that practices the invention.

Claims

1. A catheter for placement of an in situ implant, comprising:

a first elongate shaft having a proximal end and a distal end, the first shaft defining a first lumen therethrough;

a second elongate shaft having a proximal end and a distal end, the second shaft defining a second lumen therethrough;

a first sharpened distal tip disposed at the distal end of the first shaft, the first distal tip defining a lumen therethrough in fluid communication with the first lumen; and

a second sharpened distal tip disposed at the distal end of the second shaft, the second distal tip defining a lumen in fluid communication with the second lumen;

wherein the first shaft and the second shaft are fixedly secured to one another at the distal end of the first shaft and the distal end of the second shaft such that the distal end of the first shaft does not move relative to the distal end of the second shaft.

2. The catheter of claim 1 wherein the first sharpened distal tip extends beyond the second sharpened distal tip.

3. The catheter of claim 1 wherein the first elongate shaft comprises a polymer and the first sharpened distal tip comprises a metal.

4. The catheter of claim 3 wherein the second elongate shaft comprises a polymer and the second sharpened distal tip comprises a metal.

5. The catheter of claim 1 wherein the first elongate shaft and the second elongate shaft are welded together at the distal end of the first shaft and the distal end of the second shaft.

6. The catheter of claim 1 wherein the first elongate shaft and the second elongate shaft are at least 0.5 meters in length.

7. The catheter of claim 1 wherein the first sharpened distal tip is angled in a first direction and the second sharpened distal tip is angled in a second direction, the second direction being different from the first direction.

8. A catheter for placement of an in situ implant, comprising:

a first elongate shaft having a proximal end and a distal end, the first shaft defining a first lumen therethrough;

a second elongate shaft having a proximal end and a distal end, the second shaft defining a second lumen therethrough;

a first sharpened distal tip disposed at the distal end of the first shaft, the first distal tip defining a lumen therethrough in fluid communication with the first lumen; and

a second sharpened distal tip disposed at the distal end of the second shaft, the second distal tip defining a lumen in fluid communication with the second lumen;

wherein the first elongate shaft contains a polymer; and

wherein the second elongate shaft contains a cross-linking agent.

9. The catheter of claim 8 wherein the cross-linking agent is mixed with a contrast solution.

10. The catheter of claim 8 wherein the polymer is premixed with therapeutic.

11. The catheter of claim 10 wherein the polymer is alginate polymer.

12. The catheter of claim 8 wherein the position of the distal end of the second shaft is substantially fixed relative to the position of the distal end of the first shaft.

13. The catheter of claim 12 wherein the distal end of the first shaft is secured to the distal end of the second shaft by a web.

14. The catheter of claim 12 wherein the distal end of the first shaft is secured to the distal end of the second shaft by an adhesive weld.

15. A catheter for placement of an in situ implant, comprising:

a first elongate shaft having a proximal end and a distal end, the first shaft defining a first lumen therethrough;

a second elongate shaft having a proximal end and a distal end, the second shaft defining a second lumen therethrough;

a first sharpened distal tip disposed at the distal end of the first shaft, the first distal tip defining a lumen therethrough in fluid communication with the first lumen; and

a second sharpened distal tip disposed at the distal end of the second shaft, the second distal tip defining a lumen in fluid communication with the second lumen;

wherein the first shaft is formed from a biocompatible polymer; and

wherein the position of the distal end of the second shaft is substantially fixed relative to the position of the distal end of the first shaft.

16. The catheter of claim 15 wherein the first elongate shaft contains a polymer, and wherein the second elongate shaft contains a cross-linking agent.