Extraction device, analyzer, extraction method, and analysis method

• US 7,857,759 B2
• Filed: 03/25/2004
• Issued: 12/28/2010
• Est. Priority Date: 03/26/2003
• Status: Expired due to Fees

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Sato, Toshiyuki, Maekawa, Yasunori, Sawa, Kennichi, Okada, Seiki, Asano, Kaoru
• Primary Examiner(s): Mallari; Patricia C
• Assistant Examiner(s): Toth; Karen E
• Application Number:
  US10/810,412
• Publication Number:
  US 20040193219A1
• Time in Patent Office: 2,469 Days
• Field of Search: 600/345, 600/347, 600/365, 604/20
• US Class Current: 600/365
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

Extraction device for extracting an analyte from living tissue through skin are described that include: (a) a first electrode part having a contact area with the skin of less than about 50 mm²; (b) a through-current electrode part; and (c) a power supply part for supplying electrical energy to the first electrode part and the through-current electrode part, and for extracting an analyte in the first electrode part. Analyzers, extraction methods, and analysis methods are also described.

Claims

1. An extraction device for extracting an analyte in living tissue through skin, the device comprising:

a first path-forming electrode part;

a first extraction electrode part for extracting an analyte;

a through-current electrode part; and

a power supply part for supplying electrical energy to the first path-forming electrode part, the first extraction electrode part, and the through-current electrode part, for forming analyte transmission paths in the skin for the passage of the analyte, and for extracting the analyte at the first extraction electrode part;

wherein the first path-forming electrode part comprises a first path-forming electrode connected to the power supply part, and a first chamber comprising purified water/ion-conductive material, wherein the purified water/ion-conductive material contacts the first path-forming electrode;

wherein the first chamber is configured such that the purified water/ion-conductive material;

is configured to contact the skin over an area of less than 25 mm²; and

wherein, during formation of the analyte transmission paths, the first path-forming electrode part is connected to the power supply part; and

wherein, during analyte extraction, the first path-forming electrode part is disconnected from the power supply part and the first extraction electrode part is connected to the power supply part.

2. The device of claim 1, wherein the power supply part supplies a current of less than about 300 μ

A.

3. The device of claim 1, wherein the purified water/ion-conductive material is configured to contact the skin-over an area of between 0.01 and 25 mm².

4. The device of claim 1, wherein the power supply part comprises a constant-current power supply.

5. The device of claim 1, wherein the power supply part comprises a constant-voltage power supply.

6. The device of claim 1, wherein the power supply part outputs a voltage of less than about 10 V.

7. The device of claim 1, further comprising an extraction accelerator part for promoting the extraction of the analyte.

8. The device of claim 7, wherein the extraction accelerator part comprises an ultrasonic irradiation part for irradiating the skin with ultrasonic waves.

9. The device of claim 1, wherein the analyte is glucose.

10. An analyzer for analyzing an analyte extracted through skin, the analyzer comprising:

the extraction device of claim 1;

an assay part for assaying the analyte extracted in the first electrode part, and for outputting a signal corresponding to an amount of the analyte;

an analysis part for analyzing the signal output by the assay part to obtain an analysis result; and

an output part for outputting the analysis result obtained by the analysis part.

11. The device of claim 1, wherein the contact area is between 0.01 and 25 mm².

12. The device of claim 1 further comprising:

a second path-forming electrode part; and

a second extraction electrode part for extracting an analyte;

wherein the power supply part comprises;

a first power supply for supplying electrical energy to the first path-forming electrode part, the first extraction electrode part, and the through-current electrode part, for forming analyte transmission paths in the skin, and for extracting analyte at the first extraction electrode part; and

a second power supply for supplying electrical energy to the second path-forming electrode part, the second extraction electrode part, and the through-current electrode part, for forming analyte transmission paths in the skin, and for extracting analyte at the second extraction electrode part;

wherein the second path-forming electrode part comprises;

a second path-forming electrode connected to the power supply part; and

a second chamber comprising purified water/ion-conductive material, wherein the purified water/ion-conductive material contacts the second path-forming electrode;

wherein the second chamber is configured such that the purified water/ion-conductive material has a contact area with the skin of less than 25 mm²; and

mm

wherein, during formation of the analyte transmission paths, the second path-forming electrode part is connected to the power supply part; and

wherein, during analyte extraction, the second path-forming electrode part is disconnected from the power supply part and the second extraction electrode part is connected to the power supply part.