Percutaneous absorption system and percutaneous absorption method

• US 7,858,112 B2
• Filed: 02/26/2003
• Issued: 12/28/2010
• Est. Priority Date: 02/28/2002
• Status: Active Grant

• Current Assignee: Kenji Sugibayashi, Lintec Corporation
• Original Assignee: Kenji Sugibiayashi, Lintec Corporation
• Inventors: Nakagawa, Kiyose, Saito, Rui, Hatanaka, Tomio, Sugibayashi, Kenji
• Primary Examiner(s): Wax; Robert A
• Assistant Examiner(s): AHMED, HASAN SYED
• Application Number:
  US10/372,957
• Publication Number:
  US 20030161869A1
• Time in Patent Office: 2,862 Days
• Field of Search: None
• US Class Current: 424/449
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

The present invention provides a percutaneous absorption system and a percutaneous absorption method, which have a simple constitution and can realize the easy and continuous percutaneous absorption of medicine even when the medicine is formed of a water-soluble oligomer solution or a high-molecular solution. In the percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine therein and a support portion for supporting the medicine reservoir portion, the support portion including an adhesive layer and a substrate having medicine non-permeating property, the system is provided with an elastic member for applying pressure to the medicine held in the inside of the medicine reservoir portion, and by breaking the substrate having medicine non-permeating property in the support portion using a mechanical stimulus such as an injection needle or the like, the medicine is released (delivered) at a fixed rate.

Claims

1. A percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine which is insulin, calcitonin or vasopressin therein and a support portion for supporting the medicine reservoir portion on the skin surface, the support portion including an adhesive layer and a substrate having medicine non-permeating property which thickness is of 5 to 1000 μ

M,

wherein a portion or the whole of the medicine reservoir portion comprises an elastic member,

the medicine is held in the medicine holding portion under pressure in an initial value of about 1.1×

10⁵ Pa or more,

a projection is provided inside of the medicine reservoir portion,

and the substrate having medicine non-permeating property in the support portion is breakable upon receiving a mechanical stimulus given by the projection.

2. The percutaneous absorption system according to claim 1, wherein the elastic member is a foamed body.

3. The percutaneous absorption system according to claim 1, wherein the medicine reservoir portion has a substantially cylindrical shape and defines the medicine holding portion inside thereof.

4. The percutaneous absorption system according to claim 1, wherein the projection has a distal end portion thereof extended downwardly and arranged substantially in a direction perpendicular to the substrate having medicine non-permeating property.

5. The percutaneous absorption system according to claim 1, wherein the projection is mounted on an upper surface of the medicine reservoir portion and the upper surface of the medicine reservoir portion is formed of the elastic member.

6. The percutaneous absorption system according to claim 1, wherein a pushing portion which is served for pushing down the projection is formed on an end portion of the projection.

11. The percutaneous absorption system according to claim 1, wherein the initial value is up to about 2.0×

10⁵ Pa.

12. The percutaneous absorption system according to claim 1, wherein the initial value is up to about 1.8×

10⁵ Pa.

13. The percutaneous absorption system according to claim 1, wherein the medicine comprises insulin.

7. A percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine which is insulin, calcitonin or vasopressin therein and a support portion for supporting the medicine reservoir portion on the skin surface, the support portion including an adhesive layer and a substrate having medicine non-permeating property which thickness is of 5 to 1000 μ

m,

wherein gas which applies pressure to the medicine held in the medicine reservoir portion in an initial value of about 1.1×

10⁵ Pa or more, is introduced inside of the medicine holding portion,

a projection is provided inside of the medicine reservoir portion,

and the substrate having medicine non-permeating property in the support portion is breakable upon receiving a mechanical stimulus given by the projection.

8. The percutaneous absorption system according to claim 7, wherein a portion or the whole of the medicine reservoir portion is constituted of an elastic member for applying pressure to the medicine held in the medicine holding portion.

14. The percutaneous absorption system according to claim 7, wherein the medicine comprises insulin.

9. A percutaneous absorption method which uses a percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine which is insulin, calcitonin or vasopressin therein and a support portion for supporting the medicine reservoir portion to the skin surface, the support portion including an adhesive layer and a substrate having medicine non-permeating property which thickness is of 5 to 1000 μ

m, a portion or the whole of the medicine reservoir portion comprises an elastic member, and the medicine is held in the medicine holding portion under pressure in an initial value of about 1.1×

10⁵ Pa or more

wherein the method comprises mounting the percutaneous absorption system to the skin surface,

breaking at least the substrate having medicine non-permeating property in the support portion using a mechanical stimulus given by a projection provided inside of the medicine reservoir portion so that delivery of the medicine begins by pressure applied to the medicine in the initial value of about 1.1×

10⁵ Pa or more.

15. The percutaneous absorption method according to claim 9, wherein the medicine comprises insulin.

16. The percutaneous absorption method according to claim 9, wherein the medicine is administered into a stratum corneum of skin using the projection which penetrates the skin.

10. A percutaneous absorption method which uses a percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine which is insulin, calcitonin or vasopressin therein and a support portion for supporting the medicine reservoir portion on the skin surface, the support portion including an adhesive layer and a substrate having medicine non-permeating property which thickness is of 5 to 1000 μ

m,

wherein the method comprises mounting the percutaneous absorption system to the skin surface,

breaking at least the substrate having medicine non-permeating property in the support portion using a mechanical stimulus given by a projection provided inside of the medicine reservoir portion,

and delivering the medicine by applying pressure to the medicine in an initial value of about 1.1×

10⁵ Pa or more, using gas previously introduced into the medicine reservoir portion.

17. The percutaneous absorption method according to claim 10, wherein the medicine comprises insulin.

18. The percutaneous absorption method according to claim 10, wherein the medicine is administered into a stratum corneum of skin using the projection which penetrates the skin.