Particles

• US 7,858,183 B2
• Filed: 03/02/2005
• Issued: 12/28/2010
• Est. Priority Date: 03/02/2005
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Lanphere, Janel, Anderson, Steven M.
• Primary Examiner(s): Seidleck; James
• Assistant Examiner(s): HAIDER, SAIRA BANO
• Application Number:
  US11/070,967
• Publication Number:
  US 20060199009A1
• Time in Patent Office: 2,127 Days
• Field of Search: 428/325, 428402-40224, 503/215, 514/2, 264 4- 47, 424/489, 4272133-21336
• US Class Current: 428/402.2
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: Y10T 428/2984 Microcapsule with fluid core [includes liposome]

Abstract

A particle with a diameter of at most about 3,000 microns has an internal pressure of at least about 1.1 atmospheres at a temperature of less than about 25° C.

Claims

1. A particle having an internal pressure of at least about 1.1 atmospheres and at most about 5.0 atmospheres at a temperature of less than about 25°

C., wherein the particle has a diameter of at most about 3,000 microns and the particle bursts at a temperature of at most about 200°

C., and

wherein the particle comprises a gas generator, and when the gas generator is heated to a temperature of at least about 25°

C., the internal pressure of the particle increases to at least about 1.2 atmospheres.

2. The particle of claim 1, wherein the gas generator is disposed in an interior region of the particle.

3. A particle having an internal pressure of at least about 1.1 atmospheres and at most about 5.0 atmospheres at a temperature of less than about 25°

C., wherein the particle has a diameter of at most about 3,000 microns and the particle bursts at a temperature of at most about 200°

C., and

wherein the particle comprises a gas generator, and when the gas generator is heated to a temperature of at least about 35°

C., the internal pressure of the particle increases to at least about 1.5 atmospheres.

4. A particle having an internal pressure of at least about 1.1 atmospheres and at most about 5.0 atmospheres at a temperature of less than about 25°

C., wherein the particle has a diameter of at most about 3,000 microns and the particle bursts at a temperature of at most about 200°

C., and

wherein the particle comprises a gas generator, and when the gas generator is heated to a temperature of at least about 90°

C., the internal pressure of the particle increases to at least about 1.5 atmospheres.

5. A particle having an internal pressure of at least about 1.1 atmospheres and at most about 5.0 atmospheres at a temperature of less than about 25°

C., wherein the particle has a diameter of at most about 3,000 microns and the particle bursts at a temperature of at most about 200°

C., and

wherein the particle comprises a gas generator, and when the gas generator is heated to a temperature of at least about 100°

C., the internal pressure of the particle increases to at least about 1.5 atmospheres.

6. The particle of claim 5, wherein the gas generator comprises water or saline.