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Compositions of CpG and saponin adjuvants and uses thereof

  • US 7,858,589 B2
  • Filed: 03/10/2006
  • Issued: 12/28/2010
  • Est. Priority Date: 08/10/1998
  • Status: Expired due to Fees
First Claim
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1. A vaccine composition comprising:

  • (a) an antigen;

    (b) a Quillaja saponaria saponin possessing immune adjuvant activity; and

    (c) an immunostimulatory oligonucleotide comprising at least one unmethylated CpG dinucleotide, wherein the immunostimulatory oligonucleotide is not a part of a DNA vaccine vector,wherein the saponin and immunostimulatory oligonucleotide have a synergistic adjuvant effect.

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