FET-based sensor for detecting ionic material, ionic material detecting device using the FET-based sensor, and method of detecting ionic material using the FET-based sensor

• US 7,859,029 B2
• Filed: 01/09/2007
• Issued: 12/28/2010
• Est. Priority Date: 01/09/2006
• Status: Active Grant

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Yoo, Kyu-tae, Lee, Kyu-sang, Kim, Jin-tae, Shim, Jeo-young, Cho, Yeon-ja
• Primary Examiner(s): Jackson, Jr.; Jerome
• Application Number:
  US11/621,191
• Publication Number:
  US 20070159216A1
• Time in Patent Office: 1,449 Days
• Field of Search: 257/253
• US Class Current: 257/253
• CPC Class Codes: C12Q 1/6825 Nucleic acid detection involving sensors
• CPC Class Codes: G01N 27/4145 specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.

Claims

1. A FET (field-effect transistor)-based sensor for detecting an ionic material, the sensor comprising:

a sensing chamber including a reference electrode and a plurality of sensing FETs, wherein the sensing chamber is defined by a lower substrate including the plurality of sensing FETs, sidewalls, and an upper substrate functioning as the reference electrode; and

a reference chamber including a reference electrode and a plurality of reference FETs, wherein the reference chamber is defined by the lower substrate including the plurality of reference FETs, sidewalls, and the upper substrate function as the reference electrode.

2. The FET-based sensor of claim 1, wherein the sensing FETs and the reference FETs have a same structure and a same electrical characteristics.

3. The FET-based sensor of claim 1, wherein the sensing FETs and the reference FETs are each arranged in an array form.

4. The FET-based sensor of claim 1, wherein each of the sensing and reference FETs comprises:

a substrate;

a source and a drain formed in side regions of the substrate and doped with a polarity opposite to the substrate; and

a gate formed on the substrate connecting the source and the drain.

5. The FET-based sensor of claim 4, wherein the gate comprises an oxide layer and a polysilicon layer on the oxidation layer.

6. The FET-based sensor of claim 1, wherein the ionic material is a biomolecule.

7. The FET-based sensor of claim 6, wherein the biomolecule is a nucleic acid or a protein.

8. The FET-based sensor of claim 7, wherein the nucleic acid is selected from the group consisting of DNA, RNA, PNA, LNA and a hybrid thereof.

9. The FET-based sensor of claim 7, wherein the protein is selected from the group consisting of an enzyme, a substrate, an antigen, an antibody, a ligand, an aptamer and a receptor.

10. The FET-based sensor of claim 1, wherein each of the sensing chamber and the reference chamber further comprises an inlet through which a solution flows into the chamber and an outlet through which a solution flows out of the chamber.

11. The FET-based sensor of claim 1, wherein each of the sensing chamber and the reference chamber is connected to a micropump pumping a solution into and out of the chambers.

12. An ionic material detecting device comprising the FET-based sensor of claim 1.